scispace - formally typeset
Search or ask a question
Author

Debabrata Bandyopadhyay

Bio: Debabrata Bandyopadhyay is an academic researcher from University of Calcutta. The author has contributed to research in topics: Piper retrofractum & Piperaceae. The author has an hindex of 2, co-authored 2 publications receiving 44 citations.

Papers
More filters
Journal ArticleDOI
TL;DR: In this article, two unsaturated amides, retrofractamides A and C, were isolated from the total aboveground parts of Piper retroractum and were shown to be N -isobutyl-9(3′,4′-methylenedioxyphenyl)2 E,4 E,8 E -nonatrienamide from spectroscopic and chemical investigations.

42 citations


Cited by
More filters
Journal ArticleDOI
TL;DR: The secondary metabolites isolated from Piper species for the period 1907 to June 1996 have been reviewed in this paper, where nearly six hundred chemical constituents belonging to different classes of bioactive compounds are listed together with their source(s) and references.

849 citations

Journal ArticleDOI
TL;DR: Structural-activity relationships indicate that the N-isobutylamine moiety might play a crucial role in the larvicidal activity, but the methylenedioxyphenyl moiety does not appear essential for toxicity.
Abstract: The insecticidal activity of materials derived from the fruits of Piper nigrum against third instar larvae of Culex pipiens pallens, Aedes aegypti, and A. togoi was examined and compared with that of commercially available piperine, a known insecticidal compound from Piper species. The biologically active constituents of P. nigrum fruits were characterized as the isobutylamide alkaloids pellitorine, guineensine, pipercide, and retrofractamide A by spectroscopic analysis. Retrofractamide A was isolated from P. nigrum fruits as a new insecticidal principle. On the basis of 48-h LC(50) values, the compound most toxic to C. pipiens pallens larvae was pipercide (0.004 ppm) followed by retrofractamide A (0.028 ppm), guineensine (0.17 ppm), and pellitorine (0.86 ppm). Piperine (3.21 ppm) was least toxic. Against A. aegypti larvae, larvicidal activity was more pronounced in retrofractamide A (0.039 ppm) than in pipercide (0.1 ppm), guineensine (0.89 ppm), and pellitorine (0.92 ppm). Piperine (5.1 ppm) was relatively ineffective. Against A. togoi larvae, retrofractamide A (0.01 ppm) was much more effective, compared with pipercide (0.26 ppm), pellitorine (0.71 ppm), and guineensine (0.75 ppm). Again, very low activity was observed with piperine (4.6 ppm). Structure-activity relationships indicate that the N-isobutylamine moiety might play a crucial role in the larvicidal activity, but the methylenedioxyphenyl moiety does not appear essential for toxicity. Naturally occurring Piper fruit-derived compounds merit further study as potential mosquito larval control agents or as lead compounds.

203 citations

Journal ArticleDOI
TL;DR: Piper crassinervium, P. aduncum,P.
Abstract: Piper crassinervium, P aduncum, P hostmannianum, and P gaudichaudianum contain the new benzoic acid derivatives crassinervic acid (1), aduncumene (8), hostmaniane (18), and gaudichaudianic acid (20), respectively, as major secondary metabolites Additionally, 19 known compounds such as benzoic acids, chromenes, and flavonoids were isolated and identified The antifungal activity of these compounds was evaluated by bioautographic TLC assay against Cladosporium cladosporioides and C sphaerospermum

184 citations

Journal ArticleDOI
TL;DR: The n-hexane extracts of 19 Piper species, predominantly from China, were screened for their 5-lipoxygenase (5-LOX) and cyclo oxygengenase-1 (COX-1) inhibitory potential and showed considerable inhibitory activity against at least one of these two key enzymes of the arachidonic acid metabolism.

152 citations

Journal ArticleDOI
TL;DR: In this paper, twelve Piper species were extracted from the stems and leaves of P. manii and β-sitosteryl palmitate was obtained for the first time from P. brachystachyum.

130 citations