Debbie A Lawlor

TL;DR: A single nucleotide polymorphism in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers is found to be associated with lower body mass index per minor allele in current smokers and the opposite association with BMI in never and current smokers, demonstrating that novel associations may be obscured by hidden population sub-structure.

TL;DR: In this paper, the authors developed derivative estimation for two standard approaches-polynomial mixed models and spline mixed models, and compared their performance with an established method-principal component analysis through conditional expectation through a simulation study.

TL;DR: The metabolomic data available in BiB is described, profiled during pregnancy, in cord blood and during early life in the offspring, which can be examined alongside the BiB cohorts’ extensive phenotype data from questionnaires, medical, educational and social record linkage, and other ‘omics data.

TL;DR: The results show some evidence for a role of metabolic factors in eating disorders development in adolescence, and most associations had large confidence intervals and showed, for anorexia nervosa, different directions across time points.

TL;DR: The results of this study do not justify the conclusions, and the omission of the core of the results brings into question the external and internal validity of the paper.