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Deborah J. Cook
Researcher at McMaster University
Publications - 942
Citations - 165225
Deborah J. Cook is an academic researcher from McMaster University. The author has contributed to research in topics: Intensive care & Randomized controlled trial. The author has an hindex of 173, co-authored 907 publications receiving 148928 citations. Previous affiliations of Deborah J. Cook include McMaster University Medical Centre & Queen's University.
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Journal ArticleDOI
Barriers and potential solutions toward optimal prophylaxis against deep vein thrombosis for hospitalized medical patients: A survey of healthcare professionals†‡
Nancy S. Lloyd,James D. Douketis,James D. Douketis,Ji Cheng,Holger J. Schünemann,Deborah J. Cook,Lehana Thabane,Menaka Pai,Frederick A. Spencer,R. Brian Haynes +9 more
TL;DR: Interventions to bridge the gap between knowledge and practice should consider preprinted orders outlining DVT risk factors, and educating front-line care providers prior to implementation of a top-down approach.
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Vitamin K deficiency and D-dimer levels in the intensive care unit: a prospective cohort study.
TL;DR: It is concluded that vitamin K deficiency is common among critically ill patients, particularly on admission to the ICU, and that additional clinical research is warranted to determine whether vitamin K supplementation on admitted patients reduces the risk of ICU-acquired vitaminK deficiency and its attendant complications over the course of the ICu stay.
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Rates and determinants of informed consent: A case study of an international thromboprophylaxis trial
Orla Smith,Ellen McDonald,Nicole Zytaruk,Denise Foster,Andrea Matte,Laurie Meade,Nicole O’Callaghan,Shirley Vallance,Pauline Galt,Dorrilyn Rajbhandari,Marcelo G. Rocha,Sangeeta Mehta,Niall D. Ferguson,Richard I. Hall,Robert A. Fowler,Karen E. A. Burns,Ismael Qushmaq,Marlies Ostermann,Diane Heels-Ansdell,Deborah J. Cook +19 more
TL;DR: Characteristics of study centers, research infrastructure, and experience were important factors associated with successfully procuring informed consent to participate in this heparin thromboprophylaxis trial.
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A multifaceted strategy to reduce inappropriate use of frozen plasma transfusions in the intensive care unit
Donald M. Arnold,Donald M. Arnold,François Lauzier,Heather Whittingham,Qi Zhou,Mark Crowther,Mark Crowther,Ellen McDonald,Ellen McDonald,Deborah J. Cook,Deborah J. Cook +10 more
TL;DR: The behavior-change strategy modestly improved appropriate use of FP transfusions in the ICU and improving FP request form accuracy, completeness, and compliance may be required to achieve maximum effect and ensure sustainability.
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Benefit-risk ratios in the assessment of the clinical evidence of a new therapy
TL;DR: A benefit-risk ratio is proposed that quantifies for a new therapy how many therapeutic events will be achieved for each adverse event incurred and is illustrated using data from the GUSTO trial comparing tissue plasminogen activator and streptokinase in the management of patients with acute myocardial infarction.