D
Deborah J. Cook
Researcher at McMaster University
Publications - 942
Citations - 165225
Deborah J. Cook is an academic researcher from McMaster University. The author has contributed to research in topics: Intensive care & Randomized controlled trial. The author has an hindex of 173, co-authored 907 publications receiving 148928 citations. Previous affiliations of Deborah J. Cook include McMaster University Medical Centre & Queen's University.
Papers
More filters
Journal ArticleDOI
Inadequacy of intravenous heparin therapy in the initial management of venous thromboembolism
Hui N. Lee,Deborah J. Cook,Alicia Sarabia,Rose Hatala,Annette McCallum,Derek King,Gordon H. Guyatt,Julian Dobranowski,Peter Powers +8 more
TL;DR: The mean heparin bolus and initial infusion rates were significantly lower than those suggested in the literature (p<0.01) and the AH rates were comparable to historical controls but suboptimal compared with the rates of 66% at 24 hours and 81% at 48 hours reported in association with hepar in nomogram use.
Journal ArticleDOI
Physicians declining patient enrollment in a critical care trial: a case study in thromboprophylaxis.
Deborah J. Cook,Yaseen M. Arabi,Niall D. Ferguson,Diane Heels-Ansdell,Andreas Freitag,Ellen McDonald,F Clarke,Sean P. Keenan,G. Pagliarello,W. Plaxton,Margaret S. Herridge,Tim Karachi,Shirley Vallance,John F. Cade,Tim M. Crozier,S. Alves da Silva,R. Costa Filho,Nilton Brandao,Irene Watpool,T. McArdle,G. Hollinger,Y. Mandourah,Manal Al-Hazmi,Nicole Zytaruk,Neill K. J. Adhikari,Protect Investigators +25 more
TL;DR: Tracking, analyzing, interpreting and reporting the rates and reasons for physicians declining to allow their patients to be approached for enrollment provides insights into clinicians’ concerns and attitudes to trials.
Journal ArticleDOI
Multivariable fractional polynomial interaction to investigate continuous effect modifiers in a meta-analysis on higher versus lower PEEP for patients with ARDS
Benjamin Kasenda,Willi Sauerbrei,Patrick Royston,Alain Mercat,Arthur S. Slutsky,Deborah J. Cook,Gordon H. Guyatt,Laurent Brochard,Jean-Christophe M. Richard,Thomas E. Stewart,Maureen O. Meade,Matthias Briel +11 more
TL;DR: MFPI analyses suggest a nonlinear effect modification of higher PEEP ventilation by PaO2/FiO2 and oxygenation index with reduced mortality for some patients suffering from moderate ARDS.
Journal ArticleDOI
Assessment of Postresuscitation Volume Status by Bioimpedance Analysis in Patients with Sepsis in the Intensive Care Unit: A Pilot Observational Study
Bram Rochwerg,Jason H. Cheung,Christine Ribic,Faraz Lalji,Susheel Gantareddy,Nischal Ranganath,Aziz Walele,Ellen McDonald,Maureen O. Meade,Deborah J. Cook,Trevor T. Wilkieson,Catherine M. Clase,Peter J. Margetts,Azim S. Gangji +13 more
TL;DR: Baseline VL correlated with other measures of volume expansion including serum pro-BNP levels, peripheral edema, and central venous pressure, and it is feasible to use BIA to predict postresuscitation volume status and patient-important outcomes in septic ICU patients.
Journal ArticleDOI
Research Collaboration in Pediatric Critical Care Randomized Controlled Trials: A Social Network Analysis of Coauthorship.
Mark Duffett,Melissa C. Brouwers,Maureen O. Meade,Maureen O. Meade,Grace M Xu,Deborah J. Cook,Deborah J. Cook +6 more
TL;DR: The extent and patterns of collaboration among pediatric critical care trialists are described, and the most influential individuals, centers, and countries are identified.