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Deborah J. Cook
Researcher at McMaster University
Publications - 942
Citations - 165225
Deborah J. Cook is an academic researcher from McMaster University. The author has contributed to research in topics: Intensive care & Randomized controlled trial. The author has an hindex of 173, co-authored 907 publications receiving 148928 citations. Previous affiliations of Deborah J. Cook include McMaster University Medical Centre & Queen's University.
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Journal ArticleDOI
Adjudicating Bleeding Outcomes in a Large Thromboprophylaxis Trial in Critical Illness.
Donald M. Arnold,Christian Rabbat,François Lauzier,Nicole Zytaruk,Diane Heels-Ansdell,Deborah J. Cook +5 more
TL;DR: After independent quadruplicate review of 45 bleeding events, satisfactory agreement for bleeding outcomes is documented, refined the adjudication process, and calibrated adjudicators for the remainder of the trial.
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A pilot randomized controlled trial of 7 versus 14 days of antibiotic treatment for bloodstream infection on non-intensive care versus intensive care wards
Nick Daneman,Asgar H. Rishu,Ruxandra Pinto,Yaseen M. Arabi,Emilie P. Belley-Côté,Robert Cirone,Mark Downing,Deborah J. Cook,Richard I. Hall,Shay McGuinness,Lauralyn McIntyre,John Muscedere,Rachael Parke,Rachael Parke,Steven Reynolds,Benjamin A. Rogers,Yahya Shehabi,Phillip Shin,Richard P. Whitlock,Robert A. Fowler +19 more
TL;DR: It is feasible to enroll non-ICU patients in a trial of 7 versus 14 days of antibiotics for bloodstream infection, and expanding the BALANCE RCT hospital-wide has the potential to improve the timeliness and generalizability of trial results.
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Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study.
François Lauzier,Neill K. J. Adhikari,Neill K. J. Adhikari,Andrew J.E. Seely,Andrew J.E. Seely,Karen Koo,Emilie P. Belley-Côté,Emilie P. Belley-Côté,Karen E. A. Burns,Karen E. A. Burns,Deborah J. Cook,Frédérick D’Aragon,Frédérick D’Aragon,Bram Rochwerg,Michelle E. Kho,S. J. W. Oczkowksi,Erick Duan,Maureen O. Meade,Andrew G. Day,Francois Lamontagne,Francois Lamontagne +20 more
TL;DR: In trials of interventions requiring continuous titration, metrics used for defining protocol deviations have a considerable impact on the interpretation of protocol adherence.
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Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol.
Vincent I Lau,Deborah J. Cook,Robert A. Fowler,Bram Rochwerg,Jennie Johnstone,François Lauzier,John C. Marshall,John Basmaji,Diane Heels-Ansdell,Lehana Thabane,Feng Xie +10 more
TL;DR: The objective of E-PROSPECT is to determine the incremental cost-effectiveness of L. rhamnosus GG plus usual care versus usual care without probiotics in preventing VAP and other clinically important outcomes in critically ill patients admitted to the ICU.
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A Device on Trial — Intermittent Pneumatic Compression in Critical Care
TL;DR: The intensive care unit (ICU) is replete with devices used for monitoring, prevention, diagnosis, treatment, and rehabilitation in critically ill patients.