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Deborah J. Cook
Researcher at McMaster University
Publications - 942
Citations - 165225
Deborah J. Cook is an academic researcher from McMaster University. The author has contributed to research in topics: Intensive care & Randomized controlled trial. The author has an hindex of 173, co-authored 907 publications receiving 148928 citations. Previous affiliations of Deborah J. Cook include McMaster University Medical Centre & Queen's University.
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Journal ArticleDOI
Intensive versus conventional glucose control in critically ill patients.
Nice-Sugar Study Investigators,Dean R. Chittock,Steve Su,D. Blair,Denise Foster,Rinaldo Bellomo,Deborah J. Cook,Vinay Dhingra,Peter Dodek,Paul C. Hébert,William R. Henderson,Stephane Heritier,Daren K. Heyland,Colin McArthur,Ellen McDonald,Imogen Mitchell,Robyn Norton,J. Potter,Bruce G. Robinson,Juan J. Ronco +19 more
TL;DR: In this large, international, randomized trial, it was found that intensive glucose control increased mortality among adults in the ICU: a blood glucose target of 180 mg or less per deciliter resulted in lower mortality than did a target of 81 to 108 mg perDeciliter.
Journal ArticleDOI
Evidence-Based Medicine: A New Approach to Teaching the Practice of Medicine
Gordon H. Guyatt,John A. Cairns,David N. Churchill,Deborah J. Cook,Brian Haynes,Jack Hirsh,Jan Irvine,Mark Levine,Mitchell Levine,Jim Nishikawa,David L. Sackett,Patrick Brill-Edwards,Hertzel C. Gerstein,James L. Gibson,Roman Jaeschke,Anthony Kerigan,Alan J. Neville,Akbar Panju,Allan S. Detsky,Murray Enkin,Pamela Frid,Martha S. Gerrity,Andreas Laupacis,Valerie A. Lawrence,Joël Ménard,Virginia Moyer,Cynthia D. Mulrow,Paul Links,Andrew D Oxman,Jack Sinclair,Peter Tugwell +30 more
TL;DR: An important goal of the medical residency program is to educate physicians in the practice of evidence-based medicine, and strategies include a weekly, formal academic half-day for residents devoted to learning the necessary skills.
Journal ArticleDOI
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement (Chinese edition)
David Moher,Alessandro Liberati,Alessandro Liberati,Jennifer Tetzlaff,Douglas G. Altman,Gerd Antes,David C. Atkins,Virginia Barbour,N Barrowman,Jesse A. Berlin,J Clark,Mike Clarke,Mike Clarke,Deborah J. Cook,Roberto D'Amico,Roberto D'Amico,Jonathan J Deeks,Philip J. Devereaux,Kay Dickersin,M Egger,E Ernst,P C Gøtzsche,Jeremy M. Grimshaw,G Guyatt,Julian P T Higgins,Ioannidis Jpa.,Jos Kleijnen,Tom Lang,N Magrini,D McNamee,Lorenzo Moja,C Mulrow,M Napoli,A Oxman,B Pham,Drummond Rennie,Margaret Sampson,K F Schulz,P G Shekelle,David Tovey,Peter Tugwell +40 more
TL;DR: Provide a structured summary including, as applicable, background, objectives, data sources, study eligibility criteria, participants, interventions, study appraisal and synthesis methods, results, limitations, conclusions and implications of key findings, systematic review registration number 2.
Journal ArticleDOI
Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses
David Moher,David Moher,Ba' Pham,Alison Jones,Deborah J. Cook,Alejandro R. Jadad,Michael Moher,Peter Tugwell,Terry P. Klassen,Terry P. Klassen +9 more
TL;DR: Study of low methodological quality in which the estimate of quality is incorporated into the meta-analyses can alter the interpretation of the benefit of intervention, whether a scale or component approach is used in the assessment of trial quality.
Journal ArticleDOI
Multiple organ dysfunction score : a reliable descriptor of a complex clinical outcome
John C. Marshall,Deborah J. Cook,Nicolas V. Christou,Gordon R. Bernard,Charles L. Sprung,William J. Sibbald +5 more
TL;DR: This multiple organ dysfunction score, constructed using simple physiologic measures of dysfunction in six organ systems, mirrors organ dysfunction as the intensivist sees it and correlates strongly with the ultimate risk of ICU mortality and hospital mortality.