Author
Dedy Darnaedi
Other affiliations: Setsunan University, Kyoto Prefectural University of Medicine
Bio: Dedy Darnaedi is an academic researcher from Indonesian Institute of Sciences. The author has contributed to research in topics: Upuna borneensis & Gnetum gnemon. The author has an hindex of 22, co-authored 73 publications receiving 2530 citations. Previous affiliations of Dedy Darnaedi include Setsunan University & Kyoto Prefectural University of Medicine.
Papers published on a yearly basis
Papers
More filters
••
National University of Cordoba1, Addis Ababa University2, National Autonomous University of Mexico3, State University of Campinas4, United Nations Environment Programme5, UNESCO6, United States Department of Agriculture7, Indiana University8, University of British Columbia9, Commonwealth Scientific and Industrial Research Organisation10, University of Paris-Sud11, Landcare Research12, University College London13, Autonomous University of Madrid14, University of Cambridge15, Council for Scientific and Industrial Research16, University of Southern Denmark17, United Nations University18, Virginia Tech College of Natural Resources and Environment19, The Nature Conservancy20, University of the South Pacific21, University of East Anglia22, Kyushu University23, King Abdulaziz City for Science and Technology24, University of Washington25, Budapest University of Technology and Economics26, Environmental Law Institute27, Ankara University28, University of Portsmouth29, Chinese Academy of Sciences30, Indian Institute of Technology Bombay31, Kyoto University32, Joseph Fourier University33, National Scientific and Technical Research Council34, University of Yaoundé35, Polish Academy of Sciences36, University of São Paulo37, École Normale Supérieure38, University of Otago39, Stanford University40, University of Queensland41, Azim Premji University42, Helmholtz Centre for Environmental Research - UFZ43, University of Ghana44, Corvinus University of Budapest45, Stockholm University46, Lakehead University47, Indian Institute of Forest Management48, Seoul National University49, Sofia University50
TL;DR: The first public product of the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES) is its Conceptual Framework as discussed by the authors, which will underpin all IPBES functions and provide structure and comparability to the syntheses that will produce at different spatial scales, on different themes, and in different regions.
1,585 citations
••
TL;DR: Three new stilbene oligomers were isolated from the stem bark of Vatica pauciflora and elucidated by means of spectroscopic data interpretation, especially HMBC and NOESY NMR experiments.
Abstract: Three new stilbene oligomers (1-3) were isolated from the stem bark of Vatica pauciflora. The structures of a resveratrol heptamer (pauciflorol D) (1), a resveratrol dimer (pauciflorol E) (2), and an indanone derivative (pauciflorol F) (3) were elucidated by means of spectroscopic data interpretation, especially HMBC and NOESY NMR experiments.
132 citations
••
TL;DR: In this paper, the causes and history of forest loss in Indonesia from 1950 to 2015 were investigated and the authors concluded that export-oriented log production and global demand were the primary factors underlying forest loss.
122 citations
••
Kyushu University1, Kyoto University2, Australian Museum3, National University of Rosario4, University of Tokyo5, National Institute for Environmental Studies6, Smithsonian Institution7, Xishuangbanna Tropical Botanical Garden8, Kunming Institute of Botany9, Indonesian Institute of Sciences10, Royal Botanic Garden Edinburgh11, East Carolina University12, Royal Botanic Gardens13, Leiden University14, National Museum of Natural History15, Chiba University16, University of Pretoria17, University of Coimbra18
TL;DR: Fabaceae is a good proxy for overall angiosperm diversity in many habitats and that much relevant data for GLDA are available, and a truly global legume diversity assessment is called for by wider geographic collabora- tions among various scientists.
Abstract: While many plant species are considered threatened under anthropogenic pressure, it remains uncertain how rapidly we are losing plant species diversity. To fill this gap, we propose a Global Legume Diversity Assessment (GLDA) as the first step of a global plant diversity assessment. Here we describe the concept of GLDA and its feasibility by reviewing relevant approaches and data availability. We conclude that Fabaceae is a good proxy for overall angiosperm diversity in many habitats and that much relevant data for GLDA are available. As indicators of states, we propose comparison of species richness with phylogenetic and functional diversity to obtain an integrated picture of diversity. As indicators of trends, species loss rate and extinction risks should be assessed. Specimen records and plot data provide key resources for assessing legume diversity at a global scale, and distribution modeling based on these records provide key methods for assessing states and trends of legume diversity. GLDA has started in Asia, and we call for a truly global legume diversity assessment by wider geographic collabora- tions among various scientists.
88 citations
••
TL;DR: In this article, five new resveratrol oligomers; pauciflorols A, C, B, isovaticanols B and C (8), and three new oligostilbene glucosides; paupliflorosides A (11), B (13), C (14), and C(15), were isolated from the stem bark of Vatica paucifera (Dipterocarpaceae) together with known 17 resveraratrol oligomer (4, 5, 7, 9, 10, 12 and
85 citations
Cited by
More filters
••
TL;DR: Preface to the Princeton Landmarks in Biology Edition vii Preface xi Symbols used xiii 1.
Abstract: Preface to the Princeton Landmarks in Biology Edition vii Preface xi Symbols Used xiii 1. The Importance of Islands 3 2. Area and Number of Speicies 8 3. Further Explanations of the Area-Diversity Pattern 19 4. The Strategy of Colonization 68 5. Invasibility and the Variable Niche 94 6. Stepping Stones and Biotic Exchange 123 7. Evolutionary Changes Following Colonization 145 8. Prospect 181 Glossary 185 References 193 Index 201
14,171 citations
••
TL;DR: A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered.
Abstract: Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. Interest in this compound has been renewed in recent years, first from its identification as a chemopreventive agent for skin cancer, and subsequently from reports that it activates sirtuin deacetylases and extends the lifespans of lower organisms. Despite scepticism concerning its bioavailability, a growing body of in vivo evidence indicates that resveratrol has protective effects in rodent models of stress and disease. Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans.
3,509 citations
••
TL;DR: The notion of nature's contributions to people (NCP) was introduced by the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) as mentioned in this paper, a joint global effort by governments, academia, and civil society to assess and promote knowledge of Earth's biodiversity and ecosystems and their contribution to human societies.
Abstract: A major challenge today and into the future is to maintain or enhance beneficial contributions of nature to a good quality of life for all people. This is among the key motivations of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES), a joint global effort by governments, academia, and civil society to assess and promote knowledge of Earth's biodiversity and ecosystems and their contribution to human societies in order to inform policy formulation. One of the more recent key elements of the IPBES conceptual framework ( 1 ) is the notion of nature's contributions to people (NCP), which builds on the ecosystem service concept popularized by the Millennium Ecosystem Assessment (MA) ( 2 ). But as we detail below, NCP as defined and put into practice in IPBES differs from earlier work in several important ways. First, the NCP approach recognizes the central and pervasive role that culture plays in defining all links between people and nature. Second, use of NCP elevates, emphasizes, and operationalizes the role of indigenous and local knowledge in understanding nature's contribution to people.
1,470 citations
•
TL;DR: In vivo, resveratrol blocks the multistep process of carcinogenesis at various stages: it blocks carcinogen activation by inhibiting aryl hydrocarbon-induced CYP1A1 expression and activity, and suppresses tumor initiation, promotion and progression.
Abstract: Resveratrol, trans-3,5,4'-trihydroxystilbene, was first isolated in 1940 as a constituent of the roots of white hellebore (Veratrum grandiflorum O. Loes), but has since been found in various plants, including grapes, berries and peanuts. Besides cardioprotective effects, resveratrol exhibits anticancer properties, as suggested by its ability to suppress proliferation of a wide variety of tumor cells, including lymphoid and myeloid cancers; multiple myeloma; cancers of the breast, prostate, stomach, colon, pancreas, and thyroid; melanoma; head and neck squamous cell carcinoma; ovarian carcinoma; and cervical carcinoma. The growth-inhibitory effects of resveratrol are mediated through cell-cycle arrest; upregulation of p21Cip1/WAF1, p53 and Bax; down-regulation of survivin, cyclin D1, cyclin E, Bcl-2, Bcl-xL and clAPs; and activation of caspases. Resveratrol has been shown to suppress the activation of several transcription factors, including NF-kappaB, AP-1 and Egr-1; to inhibit protein kinases including IkappaBalpha kinase, JNK, MAPK, Akt, PKC, PKD and casein kinase II; and to down-regulate products of genes such as COX-2, 5-LOX, VEGF, IL-1, IL-6, IL-8, AR and PSA. These activities account for the suppression of angiogenesis by this stilbene. Resveratrol also has been shown to potentiate the apoptotic effects of cytokines (e.g., TRAIL), chemotherapeutic agents and gamma-radiation. Phamacokinetic studies revealed that the target organs of resveratrol are liver and kidney, where it is concentrated after absorption and is mainly converted to a sulfated form and a glucuronide conjugate. In vivo, resveratrol blocks the multistep process of carcinogenesis at various stages: it blocks carcinogen activation by inhibiting aryl hydrocarbon-induced CYP1A1 expression and activity, and suppresses tumor initiation, promotion and progression. Besides chemopreventive effects, resveratrol appears to exhibit therapeutic effects against cancer. Limited data in humans have revealed that resveratrol is pharmacologically quite safe. Currently, structural analogues of resveratrol with improved bioavailability are being pursued as potential therapeutic agents for cancer.
1,377 citations
••
University of Cambridge1, University of the Basque Country2, National Autonomous University of Mexico3, University of Córdoba (Spain)4, Corvinus University of Budapest5, University of Southern Denmark6, University of Gothenburg7, University of East Anglia8, Lund University9, University of Kiel10, United Nations11, Helmholtz Centre for Environmental Research - UFZ12, University of Khartoum13, King Abdulaziz City for Science and Technology14, University of Washington15, University of Oxford16, Ministry of Forestry17, University College Dublin18, National University of Cordoba19, Carthage University20, University of Chile21, Harvard University22, Norwegian University of Life Sciences23, University of Pretoria24, University of Antwerp25, Wetlands International26, Universidade Federal Rural do Rio de Janeiro27, International Union for Conservation of Nature and Natural Resources28, Council for Scientific and Industrial Research29, University of Western Australia30, National University of General Sarmiento31, Calcutta Institute of Engineering and Management32, European Commission33, Government of Canada34, Finnish Environment Institute35, Federal University of Rio de Janeiro36, Pontifical Catholic University of Rio de Janeiro37, International Institute of Minnesota38, Victoria University of Wellington39, Indian Institute of Forest Management40, University of Tokyo41
TL;DR: In this paper, the authors present the rationale for the inclusive valuation of nature's contributions to people (NCP) in decision making, as well as broad methodological steps for doing so, and argue that transformative practices aiming at sustainable futures would benefit from embracing such diversity, which require recognizing and addressing power relationships across stakeholder groups that hold different values on human nature-relations and NCP.
985 citations