Author
Deepak Patil
Other affiliations: Alfred University, University of Pardubice, Institute of Chemical Technology ...read more
Bio: Deepak Patil is an academic researcher from Washington State University. The author has contributed to research in topics: Diamond-like carbon & Thermogravimetric analysis. The author has an hindex of 22, co-authored 76 publications receiving 1370 citations. Previous affiliations of Deepak Patil include Alfred University & University of Pardubice.
Papers published on a yearly basis
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TL;DR: This work isolated the endophytic fungi from Catharanthus roseus plant and found a fungus AA-CRL-6 which produces vinblastine and vincristine in appreciable amounts and was identified as Fusarium oxysporum based upon its cultural and morphological characteristics and internal transcribed spacer (ITS) sequence analysis.
Abstract: Endophytic fungi reside in a symbiotic fashion inside their host plants, mimic their chemistry and interestingly, produce the same natural products as their hosts and are thus being screened for the production of valuable compounds like taxol, camptothecin, podophyllotoxin, etc. Vinblastine and vincristine are excellent anti-cancer drugs but their current production using plants is non-abundant and expensive. In order to make these drugs readily available to the patients at affordable prices, we isolated the endophytic fungi from Catharanthus roseus plant and found a fungus AA-CRL-6 which produces vinblastine and vincristine in appreciable amounts. These drugs were purified by TLC and HPLC and characterized using UV-Vis spectroscopy, ESI-MS, MS/MS and 1H NMR. One liter of culture filtrate yielded 76 µg and 67 µg of vinblastine and vincristine respectively. This endophytic fungal strain was identified as Fusarium oxysporum based upon its cultural and morphological characteristics and internal transcribed spacer (ITS) sequence analysis.
196 citations
TL;DR: In this article, the authors discuss the possible origin of the high thermal stability of superhard nanocomposites, prepared according to the generic concept for their design published earlier, and they show that in systems which show a strong thermodynamically driven segregation (i.e. they are immiscible), the nanostructure and resulting superhardness (measured at room temperature) remain stable up to high temperatures of ≥1100°C.
Abstract: We discuss the possible origin of the high thermal stability of our superhard nanocomposites, prepared according to the generic concept for their design published earlier. It will be shown that in systems which show a strong thermodynamically driven segregation (i.e. they are immiscible), the nanostructure and resulting superhardness (measured at room temperature) remain stable up to high temperatures of ≥1100°C. Spinodal decomposition which occurs during deposition leads to spontaneous formation of such nanostructures. The latter is fulfilled for plasma CVD of binary nanocomposites, such as nc-TiN/a-Si 3 N 4 , W 2 N/a-Si 3 N 4 , nc-VN/a-Si 3 N 4 and others deposited at a relatively high pressure of ≥1 mbar and high plasma density. In the case of plasma PVD at much lower pressure and temperature, formation of the nanostructure is not fully completed during deposition. Upon annealing, such nanocomposites show a complex structural relaxation, accompanied by an increase of the hardness, after which they remain stable up to a high temperature of ≥1000°C. This will be demonstrated by (Ti 1-x Al x )N/a-Si 3 N 4 nanocomposite coatings. Finally, we discuss the complex issue of the stability of ternary and quaternary nc-TiN/a-Si 3 N 4 / a- and nc-TiSi x nanocomposites.
134 citations
TL;DR: In this paper, it was shown that the percolative properties of phase segregation are responsible for the hardness of superhard nanocomposites, and that the formation of a nanostructure that is stable against coarsening up to relatively high temperatures is a consequence of the thermodynamically driven segregation of immiscible phases.
Abstract: It is shown that enhancement of the hardness in superhard nanocomposites is due to the percolative nature of phase segregation, which results in approximately 1-ML coverage of the transition metal nanocrystals with the non-polar Si3N4. The formation of a nanostructure that is stable against coarsening up to relatively high temperatures is a consequence of the thermodynamically driven segregation of the immiscible phases.
126 citations
TL;DR: It was found that increase in the mass proportion of IA based PUA in coatings, the coating becomes more rigid and crystalline, and decrease in viscosity of resin as concentration of synthesized UV curable PUA resin increases in conventional PUA resins.
Abstract: UV curable PUA resin was successfully synthesized from polyol based on sustainable resource originated from itaconic acid (IA), isophorone diisocyanate (IPDI) and 2-hydroxyethyl methacrylate (HEMA). A polyol was synthesized by condensation reaction of IA with 16-hexanediol in the presence of p-Toluenesulfonic acid (pTSA). The synthesized PUA resin was characterized for its structural elucidation by using Fourier Transform Infrared Spectrophotometer (FTIR), 1H and 13C NMR spectroscopy. The synthesized UV curable PUA resin was incorporated in varying concentrations in conventional PUA coating system. The effects of varying concentration of synthesized UV curable PUA resin on rheology, crystallinity, thermal and coating properties were evaluated. The rheological behavior of the resins were evaluated at variable stress and result showed decrease in viscosity of resin as concentration of synthesized UV curable PUA resin increases in conventional PUA resin. The cured coatings have been evaluated for glass transition temperature (Tg) and thermal behavior by differential scanning calorimeter and thermogravimetric analysis respectively. The degree of crystallinity of the coatings was determined from X-ray diffraction patterns using the PFM program. It was found that increase in the mass proportion of IA based PUA in coatings, the coating becomes more rigid and crystalline. The synthesized UV curable PUA coatings showed interesting mechanical, chemical, solvent and thermal properties as compared to the conventional PUA. Further, cured coatings were also evaluated for gel content and water absorption.
67 citations
TL;DR: The bio-based amine functional benzoxazine (Bnz) resin was synthesized from cardanol, N, N' -Bis(2-aminoethyl)ethane-1,2-diamine and paraformaldehyde by the Mannich condensation reaction as discussed by the authors.
58 citations
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28,685 citations
TL;DR: In this article, the physical, chemical, electrochemical and mechanical properties of pure and doped ceria, predominantly in the temperature range from 200 to 1000°C, are investigated.
1,870 citations
TL;DR: This article reviews the various common plasma techniques and experimental methods as applied to biomedical materials research, such as plasma sputtering and etching, plasma implantation, plasma deposition, plasma polymerization, laser plasma deposited, plasma spraying, and so on.
Abstract: Plasma-surface modification (PSM) is an effective and economical surface treatment technique for many materials and of growing interests in biomedical engineering This article reviews the various common plasma techniques and experimental methods as applied to biomedical materials research, such as plasma sputtering and etching, plasma implantation, plasma deposition, plasma polymerization, laser plasma deposition, plasma spraying, and so on The unique advantage of plasma modification is that the surface properties and biocompatibility can be enhanced selectively while the bulk attributes of the materials remain unchanged Existing materials can, thus, be used and needs for new classes of materials may be obviated thereby shortening the time to develop novel and better biomedical devices Recent work has spurred a number of very interesting applications in the biomedical field This review article concentrates upon the current status of these techniques, new applications, and achievements pertaining to biomedical materials research Examples described include hard tissue replacements, blood contacting prostheses, ophthalmic devices, and other products
1,404 citations
1,380 citations