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Deepali Jain

Other affiliations: Dr. Ram Manohar Lohia Hospital
Bio: Deepali Jain is an academic researcher from Maulana Azad Medical College. The author has contributed to research in topics: Leiomyoma & Bone marrow. The author has an hindex of 9, co-authored 24 publications receiving 273 citations. Previous affiliations of Deepali Jain include Dr. Ram Manohar Lohia Hospital.

Papers
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Journal ArticleDOI
TL;DR: There is paucity of compiled data over adamantinoma in the literature, hence authors tried to make a comprehensive review which must be of use to beginners and trained pathologists.
Abstract: Adamantinoma is a primary low-grade, malignant bone tumor that is predominantly located in the mid-portion of the tibia The etiology of the tumor is still a matter of debate The initial symptoms of adamantinoma are often indolent and nonspecific and depend on location and extent of the disease Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and osteofibrous components that may be intermingled with each other in various proportions and differentiating patterns To assure the histological diagnosis, pathologists should employ immunohistochemistry for demonstrating the sometimes sparse epithelial cell nests when the radiological features are suggestive of adamantinoma There is paucity of compiled data over adamantinoma in the literature, hence authors tried to make a comprehensive review which must be of use to beginners and trained pathologists Our objective is to further define the clinicoradiologic features and pathologic spectra of adamantinoma

82 citations

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TL;DR: Clinicians should consider that the occurrence of hemophagocytosis in the appropriate geographical area could be due to dengue virus infection and present with pancytopenia.
Abstract: We describe a patient with bone marrow hemophagocytosis who had classic dengue fever associated with nasal bleeding and pancytopenia. The patient recovered with appropriate supportive care. A literature search shows fewer than 20 case reports of dengue related hemophagocytosis in the English literature. Our patient is an interesting case of dengue related hemophagocytic syndrome and adds an additional case to the literature. Clinicians should consider that the occurrence of hemophagocytosis in the appropriate geographical area could be due to dengue virus infection and present with pancytopenia.

36 citations

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TL;DR: Clinicians must be aware of the varied clinical manifestations of disseminated malignant melanoma even if the primary site is not evident, in a rare case of metastatic malignant skin cancer in bone marrow with an unknown primary.
Abstract: Background Metastases of malignant melanoma to the bone marrow are very rare. A few case reports are published in the literature with a known primary site.

27 citations

Journal ArticleDOI
TL;DR: The aetiopathogenic, clinical, therapeutic and natural history of Evans syndrome is discussed and the clinical and laboratory features of six patients with Evans syndrome are reviewed.
Abstract: Evans syndrome is an uncommon condition characterised by simultaneous or sequential development of immune thrombocytopenia (ITP) and autoimmune haemolytic anaemia (AIHA) with a positive direct antiglobulin test (DAT) in the absence of a known underlying aetiology. The great majority of patients with Evans syndrome have a chronic relapsing course despite treatment, which is associated with significant morbidity and mortality. We reviewed the clinical and laboratory features of six patients with Evans syndrome. All patients had thrombocytopenia, bleeding symptoms and haemolytic anaemia with positive direct Coombs test at presentation. We discuss the aetiopathogenic, clinical, therapeutic and natural history of Evans syndrome.

27 citations

Journal ArticleDOI
TL;DR: Mixed tumours or myoepitheliomas of bone are rare and not adequately recognised primary bone tumours as mentioned in this paper.1 Mixed tumours, parachordomas and myo-peithelisomas are well defined bone malignancies.

18 citations


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Journal ArticleDOI
TL;DR: A number of recent studies have contributed to the understanding of HLH pathophysiology, leading to alternate treatment options; however, much work remains to raise awareness and improve the high morbidity and mortality of these complex conditions.
Abstract: Hemophagocytic lymphohistiocytosis (HLH) covers a wide array of related life-threatening conditions featuring ineffective immunity characterized by an uncontrolled hyperinflammatory response. HLH is often triggered by infection. Familial forms result from genetic defects in natural killer cells and cytotoxic T-cells, typically affecting perforin and intracellular vesicles. HLH is likely under-recognized, which contributes to its high morbidity and mortality. Early recognition is crucial for any reasonable attempt at curative therapy to be made. Current treatment regimens include immunosuppression, immune modulation, chemotherapy, and biological response modification, followed by hematopoietic stem-cell transplant (bone marrow transplant). A number of recent studies have contributed to the understanding of HLH pathophysiology, leading to alternate treatment options; however, much work remains to raise awareness and improve the high morbidity and mortality of these complex conditions.

329 citations

Journal Article
TL;DR: The extent of work done by various groups of scientists in India on various problems of dengue disease is reviewed, finding a lot remain to be achieved for creating an impact.
Abstract: Dengue virus belongs to family Flaviviridae, having four serotypes that spread by the bite of infected Aedes mosquitoes. It causes a wide spectrum of illness from mild asymptomatic illness to severe fatal dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS). Approximately 2.5 billion people live in dengue-risk regions with about 100 million new cases each year worldwide. The cumulative dengue diseases burden has attained an unprecedented proportion in recent times with sharp increase in the size of human population at risk. Dengue disease presents highly complex pathophysiological, economic and ecologic problems. In India, the first epidemic of clinical dengue-like illness was recorded in Madras (now Chennai) in 1780 and the first virologically proved epidemic of dengue fever (DF) occurred in Calcutta (now Kolkata) and Eastern Coast of India in 1963-1964. During the last 50 years a large number of physicians have treated and described dengue disease in India, but the scientific studies addressing various problems of dengue disease have been carried out at limited number of centres. Achievements of Indian scientists are considerable; however, a lot remain to be achieved for creating an impact. This paper briefly reviews the extent of work done by various groups of scientists in this country.

314 citations

Journal ArticleDOI
TL;DR: The causes of HUS are described, clinical, pathological, haematological and biochemical features, epidemiology and pathogenetic mechanisms as well as the biochemical, microbiological, immunological and genetic investigations leading to diagnosis are reviewed.
Abstract: Haemolytic uraemic syndrome (HUS) is defined by the simultaneous occurrence of nonimmune haemolytic anaemia, thrombocytopenia and acute renal failure. This leads to the pathological lesion termed thrombotic microangiopathy, which mainly affects the kidney, as well as other organs. HUS is associated with endothelial cell injury and platelet activation, although the underlying cause may differ. Most cases of HUS are associated with gastrointestinal infection with Shiga toxin-producing enterohaemorrhagic Escherichia coli (EHEC) strains. Atypical HUS (aHUS) is associated with complement dysregulation due to mutations or autoantibodies. In this review, we will describe the causes of HUS. In addition, we will review the clinical, pathological, haematological and biochemical features, epidemiology and pathogenetic mechanisms as well as the biochemical, microbiological, immunological and genetic investigations leading to diagnosis. Understanding the underlying mechanisms of the different subtypes of HUS enables tailoring of appropriate treatment and management. To date, there is no specific treatment for EHEC-associated HUS but patients benefit from supportive care, whereas patients with aHUS are effectively treated with anti-C5 antibody to prevent recurrences, both before and after renal transplantation.

87 citations

Journal ArticleDOI
TL;DR: Results revealed that this mouse model reproduces some histopathological effects observed in humans and supports previous findings indicating virus replication in the hepatic tissue.

73 citations