Deepali Ravel

TL;DR: It is shown that the host-derived lipid lysophosphatidylcholine (LysoPC) controls P. falciparum cell fate by repressing parasite sexual differentiation, and a major component of the sexual differentiation pathway in Plasmodium is introduced that may provide new approaches for blocking malaria transmission.

TL;DR: These findings provide a mechanistic link between EVs and vascular dysfunction during malaria infection and show that EVs are efficiently internalized by endothelial cells, where the miRNA-Argonaute 2 complexes modulate target gene expression and barrier properties.

TL;DR: The ability of 10 peptide deterGents to functionally solubilize 12 olfactory receptors demonstrates their usefulness as a new class of detergents for o aroma receptors, and possibly other G-protein coupled receptors and membrane proteins.

TL;DR: This work applies for the first time an object detection model previously used on natural images to identify cells and recognize their stages in brightfield microscopy images of malaria-infected blood to demonstrate that Faster R-CNN outperforms the authors' baseline and put the results in context of human performance.

TL;DR: This study demonstrates that cell-free protein production using commercially available kits and optimal detergents is a robust technology that can be used to produce sufficient GPCRs for biochemical, structural, and functional analyses.