D
Delphine Merino
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 37
Citations - 2838
Delphine Merino is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 25, co-authored 33 publications receiving 2260 citations. Previous affiliations of Delphine Merino include University of Burgundy & University of Melbourne.
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Journal ArticleDOI
Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2
Delphine Merino,Najoua Lalaoui,Alexandre Morizot,Pascal Schneider,Eric Solary,Olivier Micheau +5 more
TL;DR: DcR1 and DcR2 inhibit DR4- and DR5-mediated, TRAIL-induced apoptosis and it is demonstrated here that this occurs through distinct mechanisms.
Journal ArticleDOI
Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer
François Vaillant,Delphine Merino,Delphine Merino,Lily Lee,Lily Lee,Kelsey Breslin,Bhupinder Pal,Bhupinder Pal,Matthew E. Ritchie,Matthew E. Ritchie,Gordon K. Smyth,Gordon K. Smyth,Michael Christie,Michael Christie,Michael Christie,Louisa J. Phillipson,Louisa J. Phillipson,Christopher J. Burns,Christopher J. Burns,G. Bruce Mann,G. Bruce Mann,Jane E. Visvader,Jane E. Visvader,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman +25 more
TL;DR: Unexpectedly, BH3 mimetics were found to counteract the side effect of tamoxifen-induced endometrial hyperplasia and synergized with phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors in eliciting apoptosis.
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BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines.
Delphine Merino,Gemma L. Kelly,Guillaume Lessene,Andrew H. Wei,Andrew W. Roberts,Andreas Strasser,Andreas Strasser +6 more
TL;DR: The BCL-2 inhibitor venetoclax has been approved for treatment of refractory chronic lymphocytic leukemia and this drug and inhibitors of pro-survival MCL-1 and B CL-XL are being tested in diverse malignancies.
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The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins
Delphine Merino,Maybelline Giam,Maybelline Giam,Peter Hughes,Owen M. Siggs,Klaus Heger,Lorraine A. O'Reilly,Jerry M. Adams,Andreas Strasser,Erinna F. Lee,W.D. Fairlie,Philippe Bouillet +11 more
TL;DR: Analysis of mice showed that Bim's proapoptotic activity is not solely caused by its ability to engage its prosurvival relatives or solely to its binding to Bax, and initiation of apoptosis in vivo appears to require features of both models.
Journal ArticleDOI
Spatial omics and multiplexed imaging to explore cancer biology
Sabrina M. Lewis,Sabrina M. Lewis,Marie Liesse Asselin-Labat,Marie Liesse Asselin-Labat,Quan Nguyen,Jean Berthelet,Xiao Tan,Verena C. Wimmer,Verena C. Wimmer,Delphine Merino,Kelly L. Rogers,Kelly L. Rogers,Shalin H. Naik,Shalin H. Naik +13 more
TL;DR: In this article, the authors provide the current state and future perspectives on the spatial technologies expected to drive the next generation of research and diagnostic and therapeutic strategies for cancer, and provide a more comprehensive understanding of cell-to-cell variation within and between individual tumors.