D
Denham Harman
Researcher at University of Nebraska Medical Center
Publications - 76
Citations - 22445
Denham Harman is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Free-radical theory of aging & Life expectancy. The author has an hindex of 46, co-authored 76 publications receiving 21022 citations. Previous affiliations of Denham Harman include University of Nebraska–Lincoln & United States Department of Veterans Affairs.
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Journal ArticleDOI
Aging: A Theory Based on Free Radical and Radiation Chemistry
TL;DR: It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents.
Journal ArticleDOI
The Biologic Clock: The Mitochondria?
TL;DR: The author suggests that the maximal life span of a given mammalian species is largely an expression of genetic control over the rate of oxygen utilization, the rate increasing with the rates of oxygen consumption, which ultimately causes death.
Journal ArticleDOI
Oxygen Radicals and Human Disease
Carroll E. Cross,Barry Halliwell,Edward T. Borish,William A. Pryor,Bruce N. Ames,Robert L. Saul,Joe M. McCORD,Denham Harman +7 more
TL;DR: Attention is focused on cigarette smoke oxidants, ischemia-reperfusion-induced radical production, carcinogenesis, and aging, which may well provide a firm foundation for therapeutic breakthroughs in oxy-radical research.
Journal ArticleDOI
The aging process
TL;DR: It is not unreasonable to expect on the basis of present data that the healthy life span can be increased by 5-10 or more years by keeping body weight down, at a level compatible with a sense of well-being, while ingesting diets adequate in essential nutrients but designed to minimize random free radical reactions in the body.
Journal ArticleDOI
The free radical theory of aging.
TL;DR: The free radical theory of aging postulates that aging changes are caused by free radical reactions, and data indicate that average life expectancy at birth may be increased by 5 or more years, by nutritious low caloric diets supplemented with one or more free radical reaction inhibitors.