D
Denis Tsygankov
Researcher at Georgia Institute of Technology
Publications - 52
Citations - 885
Denis Tsygankov is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Biology & Dynein. The author has an hindex of 18, co-authored 40 publications receiving 756 citations. Previous affiliations of Denis Tsygankov include University of North Carolina at Chapel Hill & Emory University.
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Journal ArticleDOI
CellGeo: A computational platform for the analysis of shape changes in cells with complex geometries
Denis Tsygankov,Colleen G. Bilancia,Eric A. Vitriol,Klaus M. Hahn,Mark Peifer,Timothy C. Elston +5 more
TL;DR: The open source MATLAB application CellGeo is a user-friendly computational platform that allows simultaneous, automated tracking and analysis of dynamic changes in cell shape, including protrusions ranging from filopodia to lamellipodiato growth cones.
Journal ArticleDOI
Enabled Negatively Regulates Diaphanous-Driven Actin Dynamics In Vitro and In Vivo
Colleen G. Bilancia,Jonathan D. Winkelman,Denis Tsygankov,Stephanie H. Nowotarski,Jennifer A. Sees,Kate Comber,Iwan Robert Evans,Vinal V. Lakhani,Will J Wood,Timothy C. Elston,David R. Kovar,Mark Peifer +11 more
TL;DR: It is found that Dia and Ena have distinct biochemical properties that contribute to the different protrusion morphologies each induces, and Acting together, Ena and Dia induce protrusions distinct from those induced by either alone, with Ena reducing Dia-driven protrusion length and number.
Journal ArticleDOI
Role of competition between polarity sites in establishing a unique front
Chi-Fang Wu,Jian-geng Chiou,Maria Minakova,Benjamin Woods,Denis Tsygankov,Trevin R. Zyla,Natasha S. Savage,Timothy C. Elston,Daniel J. Lew +8 more
TL;DR: In this paper, a greedy competition between clusters to recruit and retain polarity proteins from a shared intracellular pool was studied in the model yeast Saccharomyces cerevisiae, where positive feedback can trigger growth of several Cdc42 clusters at the same time.
Journal ArticleDOI
Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms
Pei Hsuan Chu,Denis Tsygankov,Matthew E. Berginski,Onur Dagliyan,Shawn M. Gomez,Timothy C. Elston,Andrei V. Karginov,Klaus M. Hahn +7 more
TL;DR: It is demonstrated that Src family isoforms produce very different phenotypes, encompassing cell spreading, polarized motility, and production of long, thin cell extensions.
Journal ArticleDOI
Cell-cycle control of cell polarity in yeast.
TL;DR: It is reported that yeast daughter cells can polarize Cdc42 before CDK activation at start, and it is shown that G1 cyclin‐dependent kinase activity enables localization of a subset of CDC42 effectors to sites enriched for C dc42.