D
Denise Juhr
Researcher at Children's Hospital of Philadelphia
Publications - 11
Citations - 2347
Denise Juhr is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 3 publications receiving 2132 citations.
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Journal ArticleDOI
Highly Efficient miRNA-Mediated Reprogramming of Mouse and Human Somatic Cells to Pluripotency
Frederick Anokye-Danso,Chinmay M. Trivedi,Denise Juhr,Mudit Gupta,Zheng Cui,Ying Tian,Yuzhen Zhang,Wenli Yang,Peter J. Gruber,Peter J. Gruber,Jonathan A. Epstein,Edward E. Morrisey +11 more
TL;DR: It is shown that expression of the miR302/367 cluster rapidly and efficiently reprograms mouse and human somatic cells to an iPSC state without a requirement for exogenous transcription factors, and that miRNA and Hdac-mediated pathways can cooperate in a powerful way to reprogram somatics cells to pluripotency.
Journal ArticleDOI
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
Andrew Elden,Hyung-Jun Kim,Michael P. Hart,Alice Chen-Plotkin,Brian S. Johnson,Xiaodong Fang,Maria Armakola,Felix Geser,Robert W. Greene,Min Min Lu,Arun Padmanabhan,Dana Clay-Falcone,Leo McCluskey,Lauren Elman,Denise Juhr,Peter J. Gruber,Udo Rüb,Georg Auburger,John Q. Trojanowski,Virginia M.-Y. Lee,Vivianna M. Van Deerlin,Nancy M. Bonini,Aaron D. Gitler +22 more
TL;DR: It is shown that ataxin 2 (ATXN2), a polyglutamine (polyQ) protein mutated in spinocerebellar ataxia type 2, is a potent modifier of TDP-43 toxicity in animal and cellular models.
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Erratum: Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency (Cell Stem Cell (2011) 8 (376-388))
Frederick Anokye-Danso,Chinmay M. Trivedi,Denise Juhr,Mudit Gupta,Zheng Cui,Ying Tian,Yuzhen Zhang,Wenli Yang,Peter J. Gruber,Jonathan A. Epstein,Edward E. Morrisey +10 more
Journal ArticleDOI
A Child's urine is not sterile: A pilot study evaluating the Pediatric Urinary Microbiome.
TL;DR: In this paper , the authors used the expanded quantitative urine culture protocol and 16S rRNA gene sequencing to determine the age when the urobiome develops, and compared the pediatric uobome to microbiomes of adjacent urogenital niches.
Journal ArticleDOI
Pilot study of a home use cystomanometer in patients with a neurogenic bladder.
Christopher S. Cooper,M.A. Bonnett,Christopher E. Ortman,Denise Juhr,Douglas W. Storm,Gina Lockwood +5 more
TL;DR: In this article , the first home use of a handheld electronic cystomanometer with wireless data transmission to a smartphone and hospital database was reported, however, over 50% of the devices broke.