D
Denise Wagner
Researcher at International AIDS Vaccine Initiative
Publications - 15
Citations - 2310
Denise Wagner is an academic researcher from International AIDS Vaccine Initiative. The author has contributed to research in topics: Immunogen & Epitope. The author has an hindex of 7, co-authored 13 publications receiving 2179 citations.
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Journal ArticleDOI
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target.
Laura M. Walker,Sanjay Phogat,Po-Ying Chan-Hui,Denise Wagner,Pham Phung,Julie L. Goss,Terri Wrin,Melissa Simek,Steven P. Fling,Jennifer L. Mitcham,Jennifer Lehrman,Frances Priddy,Ole A. Olsen,Steven Frey,Phillip W. Hammond,Protocol G. Principal Investigators,Stephen M. Kaminsky,Timothy J. Zamb,Matthew Moyle,Wayne C. Koff,Pascal Poignard,Dennis R. Burton,Dennis R. Burton +22 more
TL;DR: High-throughput screening has revealed two new broadly neutralizing antibodies from a clade A–infected donor in Africa, which exhibit great potency and are able to neutralize a wide range of viruses from many different clades.
Journal ArticleDOI
A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals.
Laura M. Walker,Melissa Simek,Frances Priddy,Johannes S. Gach,Denise Wagner,Michael B. Zwick,Sanjay Phogat,Pascal Poignard,Dennis R. Burton,Dennis R. Burton +9 more
TL;DR: The results suggest that broad and potent serum neutralization arises in most donors through a limited number of specificities (1–2 per donor), and that key N-linked glycans were critical for expression of the epitopes recognized by the bNAb specificities in the sera.
Journal ArticleDOI
Identification of an HIV-1 clade A envelope that exhibits broad antigenicity and neutralization sensitivity and elicits antibodies targeting three distinct epitopes.
Simon Hoffenberg,Rebecca L.R. Powell,Alexei Carpov,Denise Wagner,Aaron J. Wilson,Sergei L. Kosakovsky Pond,Ross W. B. Lindsay,Heather Arendt,Joanne DeStefano,Sanjay Phogat,Pascal Poignard,Steven P. Fling,Melissa Simek,Celia C. LaBranche,David C. Montefiori,Terri Wrin,Pham Phung,Dennis R. Burton,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,C. Richter King,Christopher L. Parks,Michael J. Caulfield +23 more
TL;DR: The BG505 Env protein warrants further investigation as an HIV vaccine candidate, as a stand-alone protein, or as a component of a vaccine vector.
Journal ArticleDOI
Design of an Escherichia coli expressed HIV-1 gp120 fragment immunogen that binds to b12 and induces broad and potent neutralizing antibodies
Sanchari Bhattacharyya,Pranveer Singh,Ujjwal Rathore,Mansi Purwar,Denise Wagner,Heather Arendt,Joanne DeStefano,Celia C. LaBranche,David C. Montefiori,Sanjay Phogat,Raghavan Varadarajan,Raghavan Varadarajan,Raghavan Varadarajan +12 more
TL;DR: It is demonstrated that it is possible to elicit broadly neutralizing sera against HIV-1 in small animals by priming with b122a and boosting with gp120, which elicited broadly neutralization sera.
Design of an Escherichia coli Expressed HIV-1 gp120 Fragment Immunogen That Binds to b12 and Induces Broad
Sanchari Bhattacharyya,Pranveer Singh,Ujjwal Rathore,Mansi Purwar,Denise Wagner,Heather Arendt,Joanne DeStefano,Celia C. LaBranche,David C. Montefiori,Sanjay Phogat,Raghavan Varadarajan +10 more
TL;DR: In this article, two small fragments of HIV-1 gp120, b121a and b122a, which display about 70% of the b12 epitope and include solubility-enhancing mutations, were designed.