D
Dennis N. Boynton
Researcher at University of Michigan
Publications - 4
Citations - 41
Dennis N. Boynton is an academic researcher from University of Michigan. The author has contributed to research in topics: Chaperone-mediated autophagy & Growth hormone receptor. The author has an hindex of 2, co-authored 3 publications receiving 13 citations.
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Journal ArticleDOI
Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy.
TL;DR: Data suggest that CMA is enhanced downstream of an endocrine change resulting from whole-body ablation of GH signaling, and Snell dwarf mice have decreased protein levels of CIP2A, a well-characterized CMA target protein, without an associated change in Cip2a mRNA.
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Inhibition of class I PI3K enhances chaperone-mediated autophagy.
TL;DR: This work disentangles previously misunderstood roles of PI3Ks in CMA regulation, and reports that inhibition of class IPI3K activates chaperone-mediated autophagy in cultured cells and mice.
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Lysosomal targetomics of ghr KO mice shows chaperone-mediated autophagy degrades nucleocytosolic acetyl-coA enzymes.
S. Joseph Endicott,Alexander C. Monovich,Eric L. Huang,Evelynn I. Henry,Dennis N. Boynton,Logan J. Beckmann,Michael J. MacCoss,Richard A. Miller +7 more
TL;DR: In this paper, the authors used a cell culture approach to show that CMA is necessary and sufficient to regulate the abundance of ACLY and ACSS2, two enzymes that produce nucleocytosolic (but not mitochondrial) acetyl-coA.
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Metastatic renal cell carcinoma in the bladder following complex partial nephrectomy: A case report
TL;DR: In this article , the authors presented a case of a 74-year-old patient with a metachronous, solitary metastasis of RCC to the bladder twenty months after partial nephrectomy and JJ-stent placement for a complex renal tumor.