Dennis R. Ownby

TL;DR: It is suggested that neonatal gut microbiome dysbiosis might promote CD4+ T cell dysfunction associated with childhood atopy, and the effect of NGM3 fecal water on relativeCD4+CD25+FOXP3+ cell abundance.

TL;DR: Exposure to 2 or more dogs or cats in the first year of life may reduce subsequent risk of allergic sensitization to multiple allergens during childhood.

TL;DR: Adherence to ICS is poor among adult patients with asthma and is correlated with several poor asthma-related outcomes, and less than perfect adherence appears to account for the majority of asthma- related hospitalizations.

TL;DR: The results reveal that exposure to dog-associated household dust results in protection against airway allergen challenge and a distinct gastrointestinal microbiome composition, and identifies L. johnsonii as a pivotal species within the gastrointestinal tract capable of influencing adaptive immunity at remote mucosal surfaces in a manner that is protective against a variety of respiratory insults.

TL;DR: Despite widespread exposure to household allergens, the strongest relationship between exposure and sensitization was seen in the bedroom and suggested that exposure to low doses of allergen, 2 U/g or less, was a risk factor and that the risk plateaus above 4 U/G.