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Derek Fleming
Researcher at Texas Tech University Health Sciences Center
Publications - 24
Citations - 815
Derek Fleming is an academic researcher from Texas Tech University Health Sciences Center. The author has contributed to research in topics: Biofilm & Pseudomonas aeruginosa. The author has an hindex of 7, co-authored 21 publications receiving 477 citations. Previous affiliations of Derek Fleming include Mayo Clinic & Texas Tech University.
Papers
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Journal ArticleDOI
Approaches to Dispersing Medical Biofilms.
Derek Fleming,Kendra P. Rumbaugh +1 more
TL;DR: This review addresses the current state of research into medical biofilm dispersal and focuses on three major classes of dispersal agents: enzymes, antibiofilm peptides, and dispersal molecules (including dispersal signals, anti-matrix molecules, and sequestration molecules).
Journal ArticleDOI
Glycoside Hydrolases Degrade Polymicrobial Bacterial Biofilms in Wounds.
TL;DR: The data suggest that glycoside hydrolase therapy represents a potential safe, effective, and new avenue of treatment for biofilm-related infections.
Journal ArticleDOI
The Consequences of Biofilm Dispersal on the Host
Derek Fleming,Kendra P. Rumbaugh +1 more
TL;DR: It is found that large-scale, in vivo dispersal of motile biofilm bacteria by glycoside hydrolases caused lethal septicemia in the absence of antibiotic therapy in a mouse wound model, but when administered prudently, biofilm degrading enzymes had the potential to potentiate the efficacy of antibiotics and help resolve biofilm-associated wound infections.
Book ChapterDOI
Host Responses to Biofilm.
TL;DR: While pathogenicBiofilms contribute to states of chronic inflammation, probiotic Lactobacillus biofilms cause a negligible immune response and, in states of inflammation, exhibit robust antiinflammatory properties.
Journal ArticleDOI
Co-infecting microorganisms dramatically alter pathogen gene essentiality during polymicrobial infection.
Carolyn B. Ibberson,Apollo Stacy,Derek Fleming,Justine L. Dees,Kendra P. Rumbaugh,Michael S. Gilmore,Marvin Whiteley +6 more
TL;DR: It is discovered that co-infection of murine surgical wounds with Pseudomonas aeruginosa results in conversion of ∼25% of the in vivo S. aureus mono-culture essential genes to non-essential, illustrating the importance of studying pathogen gene essentiality in polymicrobial communities.