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Author

Derek Griffiths

Other affiliations: Southmead Hospital
Bio: Derek Griffiths is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Urinary incontinence & Overactive bladder. The author has an hindex of 34, co-authored 84 publications receiving 17444 citations. Previous affiliations of Derek Griffiths include Southmead Hospital.


Papers
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Journal ArticleDOI
TL;DR: The standardisation of terminology of lower urinary tract function: Report from the standardistation sub-committee of the International Continence Society.
Abstract: The standardisation of terminology of lower urinary tract function: Report from the standardistation sub-committee of the International Continence Society.

7,467 citations

Journal ArticleDOI
01 Jan 2003-Urology
TL;DR: The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International ContinenceSociety.

4,293 citations

Journal ArticleDOI
TL;DR: This report restates the ICS principle that symptoms, signs and conditions are separate categories and adds a category of urodynamic observations and conditions associated with lower urinary tract dysfunction and UDS, for use in all patient groups from children to the elderly.

1,637 citations

Journal ArticleDOI
TL;DR: The neural control of micturition is reviewed and how disruption of this control leads to abnormal storage and release of urine.
Abstract: Micturition, or urination, occurs involuntarily in infants and young children until the age of 3 to 5 years, after which it is regulated voluntarily. The neural circuitry that controls this process is complex and highly distributed: it involves pathways at many levels of the brain, the spinal cord and the peripheral nervous system and is mediated by multiple neurotransmitters. Diseases or injuries of the nervous system in adults can cause the re-emergence of involuntary or reflex micturition, leading to urinary incontinence. This is a major health problem, especially in those with neurological impairment. Here we review the neural control of micturition and how disruption of this control leads to abnormal storage and release of urine.

1,138 citations

Journal ArticleDOI
TL;DR: This report contains a recommendation for a provisional standard method for defining obstruction on the basis of pressure-flow data and more detailed analyses of Pressure-flow relationships, described below, are advisable to aid diagnosis and to quantify data for research studies.
Abstract: textThe 1988 version of the collated reports on standardisation of terminology, which appeared in Neurourology and Urodynamics, vol. 7, pp. 403–427, contains material relevant to pressure flow studies in many different sections. This report is a revision and expansion of Sections 4.2 and 4.3 and parts of Sections 6.2 and 7 of the 1988 report. It contains a recommendation for a provisional standard method for defining obstruction on the basis of pressure-flow data. 2. Evaluation of Micturition 2.1. Pressure-Flow Studies At present, the best method of analysing voiding function quantitatively is the pressure-flow study of micturition, with simultaneous recording of abdominal, intravesical and detrusor pressures and flow rate (Fig. A.1.6.1). Direct inspection of the raw pressure and flow data before, during and at the end of micturition is essential, because it allows artefacts and untrustworthy data to be recognised and eliminated. More detailed analyses of pressure-flow relationships, described below, are advisable to aid diagnosis and to quantify data for research studies. The flow pattern in a pressure-flow study should be representative of free flow studies in the same patient. It is important to eliminate artefacts and unrepresentative studies before applying more detailed analyses. Pressure-flow studies contain information about the behaviour of the urethra and the behaviour of the detrusor.

423 citations


Cited by
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Journal ArticleDOI
TL;DR: The standardisation of terminology of lower urinary tract function: Report from the standardistation sub-committee of the International Continence Society.
Abstract: The standardisation of terminology of lower urinary tract function: Report from the standardistation sub-committee of the International Continence Society.

7,467 citations

Journal ArticleDOI
01 Jan 2003-Urology
TL;DR: The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International ContinenceSociety.

4,293 citations

Journal ArticleDOI
TL;DR: Next to existing terminology of the lower urinary tract, due to its increasing complexity, the terminology for pelvic floor dysfunction in women may be better updated by a female‐specific approach and clinically based consensus report.
Abstract: Introduction and hypothesis Next to existing terminology of the lower urinary tract, due to its increasing complexity, the terminology for pelvic floor dysfunction in women may be better updated by a female-specific approach and clinically based consensus report. Methods This report combines the input of members of the Standardization and Terminology Committees of two Inter

2,500 citations

Journal ArticleDOI
TL;DR: The EPIC study is the largest population-based survey to assess prevalence rates of OAB, UI, and other LUTS in five countries and is the first study to evaluate these symptoms simultaneously using the 2002 ICS definitions.

2,275 citations

Journal ArticleDOI
TL;DR: The NOBLE studies do not support the commonly held notion that women are considerably more likely than men to have urgency-related bladder control problems, and overactive bladder, with and without urge incontinence, has a clinically significant impact on quality-of-life, quality- of-sleep, and mental health, in both men and women.
Abstract: Context: the National Overactive BLadder Evaluation (NOBLE) Program was initiated to better understand the prevalence and burden of overactive bladder in a broad spectrum of the United States population. Objective: to estimate the prevalence of overactive bladder with and without urge incontinence in the US, assess variation in prevalence by sex and other factors, and measure individual burden. Design: US national telephone survey using a clinically validated interview and a follow-up nested study comparing overactive bladder cases to sex- and age-matched controls. Setting: noninstitutionalized US adult population. Participants: a sample of 5,204 adults ≥18 years of age and representative of the US population by sex, age, and geographical region. Main outcome measures: prevalence of overactive bladder with and without urge incontinence and risk factors for overactive bladder in the US. In the nested case-control study, SF-36, CES-D, and MOS sleep scores were used to assess impact. Results: the overall prevalence of overactive bladder was similar between men (16.0%) and women (16.9%), but sex-specific prevalence differed substantially by severity of symptoms. In women, prevalence of urge incontinence increased with age from 2.0% to 19% with a marked increase after 44 years of age, and in men, increased with age from 0.3% to 8.9% with a marked increase after 64 years of age. Across all age groups, overactive bladder without urge incontinence was more common in men than in women. Overactive bladder with and without urge incontinence was associated with clinically and significantly lower SF-36 quality-of-life scores, higher CES-D depression scores, and poorer quality of sleep than matched controls. Conclusions: the NOBLE studies do not support the commonly held notion that women are considerably more likely than men to have urgency-related bladder control problems. The overall prevalence of overactive bladder does not differ by sex; however, the severity and nature of symptom expression does differ. Sex-specific anatomic differences may increase the probability that overactive bladder is expressed as urge incontinence among women compared with men. Nonetheless, overactive bladder, with and without incontinence, has a clinically significant impact on quality-of-life, quality-of-sleep, and mental health, in both men and women.

2,017 citations