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Derek J. Platt
Researcher at Washington University in St. Louis
Publications - 17
Citations - 2188
Derek J. Platt is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Zika virus & Sting. The author has an hindex of 11, co-authored 16 publications receiving 1811 citations. Previous affiliations of Derek J. Platt include Tennessee State University.
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Journal ArticleDOI
A Mouse Model of Zika Virus Pathogenesis
Helen M. Lazear,Jennifer Govero,Amber M. Smith,Derek J. Platt,Estefania Fernandez,Jonathan J. Miner,Michael S. Diamond +6 more
TL;DR: Ifnar1(-/-) mice sustained high viral loads in the brain and spinal cord, consistent with evidence that ZIKV causes neurodevelopmental defects in human fetuses and valuable for evaluating vaccines and therapeutics as well as understanding disease pathogenesis.
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Zika virus infection damages the testes in mice
Jennifer Govero,Prabagaran Esakky,Suzanne M. Scheaffer,Estefania Fernandez,Andrea M. Drury,Derek J. Platt,Matthew J. Gorman,Justin M. Richner,Elizabeth A. Caine,Vanessa Salazar,Kelle H. Moley,Michael S. Diamond +11 more
TL;DR: In addition to transmission by mosquitoes, ZIKV can be detected in the seminal fluid of affected males for extended periods of time and transmitted sexually as mentioned in this paper, and the consequences of infection in the male reproductive tract of mice were evaluated.
Journal ArticleDOI
Structural Basis of Zika Virus-Specific Antibody Protection.
Haiyan Zhao,Estefania Fernandez,Kimberly A. Dowd,Scott D. Speer,Derek J. Platt,Matthew J. Gorman,Jennifer Govero,Christopher A. Nelson,Theodore C. Pierson,Michael S. Diamond,Daved H. Fremont +10 more
TL;DR: The results suggest that DIII is targeted by multiple type-specific antibodies with distinct neutralizing activity, which provides a path for developing prophylactic antibodies for use in pregnancy or designing epitope-specific vaccines against ZIKV.
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Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype
Kimberly A. Dowd,Christina R. DeMaso,Rebecca S. Pelc,Scott D. Speer,Alexander R. Y. Smith,Leslie Goo,Derek J. Platt,John R. Mascola,Barney S. Graham,Mark J. Mulligan,Michael S. Diamond,Julie E. Ledgerwood,Theodore C. Pierson +12 more
TL;DR: Because this study only defines a single ZikV serotype, vaccine candidates eliciting robust neutralizing antibody responses should inhibit infection of both ZIKV lineages, including strains circulating in the Americas.
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STING-associated vasculopathy develops independently of IRF3 in mice
James D. Warner,Ricardo A. Irizarry-Caro,Brock G. Bennion,Teresa L. Ai,Amber M. Smith,Cathrine A. Miner,Tomomi Sakai,Vijay K. Gonugunta,Jianjun Wu,Derek J. Platt,Nan Yan,Jonathan J. Miner +11 more
TL;DR: The SAVI-associated STING N153S mutation triggers IRF3-independent immune cell dysregulation and lung disease in mice and causes myeloid cell expansion, T cell cytopenia, and dysregulation of immune cell signaling.