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Derek Pickard
Researcher at Wellcome Trust Sanger Institute
Publications - 103
Citations - 7413
Derek Pickard is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Salmonella typhi & Genome. The author has an hindex of 38, co-authored 97 publications receiving 6519 citations.
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Journal ArticleDOI
Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study.
Laura García-Álvarez,Matthew T. G. Holden,Heather Lindsay,Cerian R. Webb,Derek F. J. Brown,Martin D. Curran,Enid Walpole,Karen Brooks,Derek Pickard,Christopher Teale,Julian Parkhill,Stephen D. Bentley,Giles Edwards,E Kirsty Girvan,Angela M. Kearns,Bruno Pichon,Robert Hill,Anders Rhod Larsen,Robert Skov,Sharon J. Peacock,Duncan J. Maskell,Mark A. Holmes +21 more
TL;DR: The discovery of a strain of S aureus isolated from bulk milk that was phenotypically resistant to meticillin but tested negative for the mecA gene is reported and new diagnostic guidelines for the detection of MRSA should consider the inclusion of tests for mecALGA251.
Journal ArticleDOI
Emergence and global spread of epidemic healthcare-associated Clostridium difficile.
Miao He,Fabio Miyajima,Paul Roberts,Louise Ellison,Derek Pickard,Melissa J. Martin,Thomas R. Connor,Simon R. Harris,Derek Fairley,Kathleen B. Bamford,Kathleen B. Bamford,Stephanie d’Arc,Stephanie d’Arc,Jon S. Brazier,Derek J. Brown,J. E. Coia,Gill Douce,Dale N. Gerding,Heejung Kim,Tse Hsien Koh,Haru Kato,Mitsutoshi Senoh,Tom Louie,Stephen L. Michell,Emma Butt,Sharon J. Peacock,Nicholas M. Brown,Nicholas M. Brown,Thomas V. Riley,Glen Songer,Mark H. Wilcox,Munir Pirmohamed,Ed J. Kuijper,Peter M. Hawkey,Brendan W. Wren,Gordon Dougan,Julian Parkhill,Trevor D. Lawley +37 more
TL;DR: This analysis identifies key genetic changes linked to the rapid transcontinental dissemination of epidemic C. difficile 027/BI/NAP1 and highlights the routes by which it spreads through the global healthcare system.
Journal ArticleDOI
Targeted Restoration of the Intestinal Microbiota with a Simple, Defined Bacteriotherapy Resolves Relapsing Clostridium difficile Disease in Mice
Trevor D. Lawley,Simon Clare,Alan W. Walker,Mark D. Stares,Thomas R. Connor,Claire Raisen,David Goulding,Roland Rad,Fernanda Schreiber,Cordelia Brandt,Laura J. Deakin,Derek Pickard,Sylvia H. Duncan,Harry J. Flint,Taane G. Clark,Julian Parkhill,Gordon Dougan +16 more
TL;DR: A rational approach to harness the therapeutic potential of health-associated microbial communities to treat C. difficile disease and potentially other forms of intestinal dysbiosis is demonstrated.
Journal ArticleDOI
Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways.
Nicholas R. Thomson,Debra J. Clayton,Daniel Windhorst,Georgios S. Vernikos,Susanne Davidson,Carol Churcher,Michael A. Quail,Mark P. Stevens,Michael Jones,Michael Watson,Andy Barron,Abigail N. Layton,Derek Pickard,Robert A. Kingsley,Alex Bignell,Louise Clark,Barbara Harris,Doug Ormond,Zahra Abdellah,Karen Brooks,Inna Cherevach,Tracey Chillingworth,John Woodward,Halina Norberczak,Angela Lord,Claire Arrowsmith,Kay Jagels,Sharon Moule,Karen Mungall,Mandy Sanders,Sally Whitehead,José A. Chabalgoity,Duncan J. Maskell,Tom J. Humphrey,Mark Roberts,Paul A. Barrow,Gordon Dougan,Julian Parkhill +37 more
TL;DR: Genome comparisons between these and other Salmonella isolates indicate that S. Gallinarum 287/91 is a recently evolved descendent of S. Enteritidis, and it is proposed that experimental analysis in chickens and mice could provide an experimentally tractable route toward unraveling the genetic basis of host adaptation in S. enterica.
Journal ArticleDOI
Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events
Vanessa K. Wong,Vanessa K. Wong,Stephen Baker,Stephen Baker,Stephen Baker,Derek Pickard,Julian Parkhill,Andrew J. Page,Nicholas A. Feasey,Robert A. Kingsley,Robert A. Kingsley,Nicholas R. Thomson,Nicholas R. Thomson,Jacqueline A. Keane,François-Xavier Weill,David J. Edwards,Jane Hawkey,Simon R. Harris,Alison E. Mather,Amy K. Cain,James Hadfield,Peter J. Hart,Nga Tran Vu Thieu,Elizabeth J. Klemm,Dafni A. Glinos,Robert F. Breiman,Robert F. Breiman,Robert F. Breiman,Conall H. Watson,Samuel Kariuki,Samuel Kariuki,Melita A. Gordon,Robert S. Heyderman,Chinyere K. Okoro,Jan Jacobs,Jan Jacobs,Octavie Lunguya,W. John Edmunds,Chisomo L. Msefula,José A. Chabalgoity,Mike Kama,Kylie Jenkins,Shanta Dutta,Florian Marks,Josefina Campos,Corinne N. Thompson,Corinne N. Thompson,Stephen K. Obaro,Calman A. MacLennan,Calman A. MacLennan,Calman A. MacLennan,Christiane Dolecek,Karen H. Keddy,Anthony M. Smith,Christopher M. Parry,Christopher M. Parry,Abhilasha Karkey,E. Kim Mulholland,James Campbell,James Campbell,Sabina Dongol,Buddha Basnyat,Muriel Dufour,Don Bandaranayake,Take Toleafoa Naseri,Shalini Singh,Mochammad Hatta,Paul N. Newton,Paul N. Newton,Robert S. Onsare,Lupeoletalalei Isaia,David A. B. Dance,David A. B. Dance,Viengmon Davong,Guy E. Thwaites,Guy E. Thwaites,Lalith Wijedoru,John A. Crump,Elizabeth de Pinna,Satheesh Nair,Eric J. Nilles,Duy Pham Thanh,Paul Turner,Paul Turner,Paul Turner,Sona Soeng,Mary Valcanis,Joan Powling,Karolina Dimovski,Geoff Hogg,Jeremy Farrar,Jeremy Farrar,Kathryn E. Holt,Gordon Dougan +93 more
TL;DR: This whole-genome sequence analysis of Salmonella enterica serovar Typhi identifies a single dominant MDR lineage, H58, that has emerged and spread throughout Asia and Africa over the last 30 years, and identifies numerous transmissions of H58.