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Derek Toomre
Researcher at Yale University
Publications - 134
Citations - 16048
Derek Toomre is an academic researcher from Yale University. The author has contributed to research in topics: Exocytosis & Golgi apparatus. The author has an hindex of 46, co-authored 121 publications receiving 14763 citations. Previous affiliations of Derek Toomre include European Bioinformatics Institute & University of California, Berkeley.
Papers
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Journal ArticleDOI
Lipid rafts and signal transduction
Kai Simons,Derek Toomre +1 more
TL;DR: It is now becoming clear that lipid micro-environments on the cell surface — known as lipid rafts — also take part in this process of signalling transduction, where protein–protein interactions result in the activation of signalling cascades.
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Spatial control of EGF receptor activation by reversible dimerization on living cells
TL;DR: Interestingly, dimers were enriched in the cell periphery in an actin- and receptor-expression-dependent fashion, resulting in a peripheral enhancement of EGF-induced signalling that may enable polarized responses to growth factors.
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Multicolour imaging of post-Golgi sorting and trafficking in live cells
TL;DR: Differences between apical and basolateral carriers as well as new 'hot spots' for exocytosis are revealed and lateral segregation in the trans-Golgi network is the primary sorting event.
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Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane
TL;DR: It is shown that on stimulation, dendritic cells generate tubules from lysosomal compartments that go on to fuse directly with the plasma membrane that comprise the terminal degradative compartment of the endocytic pathway from which exogenous components generally cannot be recovered intact.
Journal ArticleDOI
Video-rate nanoscopy using sCMOS camera-specific single-molecule localization algorithms
Fang Huang,Tobias M.P. Hartwich,Tobias M.P. Hartwich,Tobias M.P. Hartwich,Felix Rivera-Molina,Yu Lin,Whitney C. Duim,Jane J. Long,Pradeep D. Uchil,Jordan R. Myers,Michelle A. Baird,Walther Mothes,Michael W. Davidson,Derek Toomre,Joerg Bewersdorf +14 more
TL;DR: Algorithms are presented that overcome limitations in sCMOS-intrinsic pixel-dependent readout noise and provide unbiased, precise localization of single molecules at the theoretical limit and demonstrate single-molecule localization super-resolution imaging in fixed and living cells.