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Dervilla M.X. Donnelly

Bio: Dervilla M.X. Donnelly is an academic researcher from University College Dublin. The author has contributed to research in topics: Aryl & Armillaria mellea. The author has an hindex of 25, co-authored 112 publications receiving 1674 citations. Previous affiliations of Dervilla M.X. Donnelly include Université Paul Cézanne Aix-Marseille III.
Topics: Aryl, Armillaria mellea, Dalbergia, Ketone, Fomes


Papers
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Journal ArticleDOI
TL;DR: It is interesting to note that there has been a slight decrease in the number of new isoflavones isolated during this review period, which may be a temporary slow down in productivity and may also indicate that new compounds are becoming harder to find.

102 citations

Journal ArticleDOI
TL;DR: Palladium-catalysed coupling of the 4-chloro- or 4-bromo-coumarins 1–4 with arylboronic acids 5–13 under the Suzuki reaction conditions constitutes an efficient access to 4-arylcou marins.
Abstract: Palladium-catalysed coupling of the 4-chloro- or 4-bromo-coumarins 1–4 with arylboronic acids 5–13 under the Suzuki reaction conditions constitutes an efficient access to 4-arylcoumarins. These 4-arylcoumarins can also be obtained in good yields (70–97%) by treatment of 4-trifluoromethyl-sulfonyloxycoumarins 35–38 with arylboronic acids under modified Suzuki reaction conditions, involving the use of copper(I) iodide as a co-catalyst.

73 citations

Journal ArticleDOI
TL;DR: In this paper, the constitution of melannein was established, and the synthesis of O-dimethylmelannein and O-diethylmelanein were described.

66 citations

Journal ArticleDOI
TL;DR: Two new sesquiterpene aryl eters, 4-O-methylmelleolide and judeol, isolated from the mycelial extract of Armillaria mellea showed strong antibacterial activity against gram-positive bacteria.
Abstract: Investigation of the mycelial extract of Armillaria mellea led to the isolation of the known melleolide (2a) and two new sesquiterpene aryl eters, 4-O-methylmelleolide (2b) and judeol (1c). Their structures were deduced from spectral data and that of (2b) confirmed by X-ray analysis. The new esters (1c) and (2b) showed strong antibacterial activity against gram-positive bacteria.

48 citations


Cited by
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Journal ArticleDOI
TL;DR: Some of the recent advances in flavonoid research are reviewed and the role of anthocyanins and flavones in providing stable blue flower colours in the angiosperms is outlined.

3,465 citations

Journal ArticleDOI
TL;DR: The palladium-catalyzed cross-coupling reaction between organoboron compounds and organic halides or triflates provides a powerful and general methodology for the formation of carbon-carbon bonds as discussed by the authors.

2,712 citations

Journal ArticleDOI
TL;DR: Privileged substructures are believed to achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns.
Abstract: Privileged substructures are of potentially great importance in medicinal chemistry. These scaffolds are characterized by their ability to promiscuously bind to a multitude of receptors through a variety of favorable characteristics. This may include presentation of their substituents in a spatially defined manner and perhaps also the ability to directly bind to the receptor itself, as well as exhibiting promising characteristics to aid bioavailability of the overall molecule. It is believed that some privileged substructures achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns. As a result, these structures represent a promising means by which new lead compounds may be identified.

2,620 citations

Journal ArticleDOI
TL;DR: New, effective, and more environmentallybenignmethodologiesfortheformation of(cyclo)alkyl-aryl bonds, which require a reduced number of synthetic operations, have emerged as valuable alternatives to the conventional cross-coupling reactions.
Abstract: Transition metal-catalyzed cross-coupling reactions of alkyl metals and aryl halides or pseudohalides have emerged as a powerful methodology for the formation of Csp3-Csp2 bonds over the past decades.1 However, significant attention has also been focused on Pdand Ni-catalyzed Csp3-Csp2 bond-forming reactions that involve aryl metals and haloalkyl compounds lacking -hydrogen atoms as cross-coupling partners.2 In contrast, until a few years ago, few examples were reported in the literature concerning transition metalcatalyzed reactions of aryl metals with functionalized alkyl halides including R-halocarbonyl compounds and R-bromosulfones bearing -hydrogen atoms,3 and a single example of Pd-catalyzed cross-coupling reaction of aryl metals and unfunctionalized alkyl halides bearing -hydrogen atoms had been described.4 Only in recent years, successful procedures for the Pd-,5 Ni-,6 Rh-,7 Fe-,8 V-,9 Co-,10 and Cu-catalyzed11 cross-coupling reactions of aryl metals and unfunctionalized alkyl halides bearing -hydrogen atoms have been developed.12 Nevertheless, new, effective, and more environmentallybenignmethodologiesfortheformationof(cyclo)alkyl-aryl bonds, which require a reduced number of synthetic operations, have emerged as valuable alternatives to the conventional cross-coupling reactions. These methodologies (Scheme 1) are based on transition metal-catalyzed simple or 2-fold C-H bond functionalization according to the following approaches: (a) highly regioselective Pd-catalyzed direct arylation reactions of unactivated sp3-hybridized C-H bonds with aryl halides (eq a, Scheme 1);13 (b) Pd-catalyzed direct alkylation reactions of aryl C-H bonds with alkyl metals (eq b, Scheme 1);14 Au-15 or Pdcatalyzed16 direct alkylation reactions of aryl C-H bonds with alkyl halides or pseudohalides (eq c, Scheme 1); (d) Pd-catalyzed arylations of unactivated sp3-hybridized C-H bonds with aryl metals (eq d, Scheme 1);14c (e) Pd-, Ru-, or Cu-catalyzed cross-coupling reactions of sp3-hybridized C-H bonds with arylboronic acids using air as oxidant (eq d, Scheme 1);17 and (f) cross-dehydrogenative coupling of alkyl and aryl C-H bonds (eq e, Scheme 1).18 Finally, great attention, particularly in the past decade, has also been focused on the design, development, and application of transition metal-catalyzed coupling reactions of aryl halides and pseudohalides with a wide variety of substrates containing activated sp3-hybridized C-H bonds (eq f, Scheme 1). A mini-review on this topic was published by Scolastico and Poli in 1999,19 and three excellent reviews that concern the results obtained in this rapidly growing area of extensive research by the groups of Miura, Natsume, Hartwig, and Buchwald up to the end of 2002 were published by Miura,20 Hartwig,21 and Lloyd-Jones22 a few years later. However, the reviews by Miura20 and Hartwig21 were limited in that they fundamentally emphasized the author’s own work and * To whom correspondence should be addressed. E-mail: rossi@dcci.unipi.it. Chem. Rev. 2010, 110, 1082–1146 1082

752 citations

Journal ArticleDOI
TL;DR: More than 450 new flavonoid structures, reported from January 2001 until December 2003, are reviewed and the biological activity of some of the compounds is discussed.

656 citations