D
Despina G. Contopoulos-Ioannidis
Researcher at Stanford University
Publications - 111
Citations - 7698
Despina G. Contopoulos-Ioannidis is an academic researcher from Stanford University. The author has contributed to research in topics: Randomized controlled trial & Medicine. The author has an hindex of 36, co-authored 96 publications receiving 6890 citations. Previous affiliations of Despina G. Contopoulos-Ioannidis include University of Ioannina & Children's National Medical Center.
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Journal ArticleDOI
Replication validity of genetic association studies.
John P. A. Ioannidis,Evangelia E. Ntzani,Thomas A Trikalinos,Despina G. Contopoulos-Ioannidis,Despina G. Contopoulos-Ioannidis +4 more
TL;DR: It is concluded that a systematic meta-analytic approach may assist in estimating population-wide effects of genetic risk factors in human disease.
Journal ArticleDOI
Comparison of Evidence of Treatment Effects in Randomized and Nonrandomized Studies
John P. A. Ioannidis,Anna-Bettina Haidich,Maroudia Pappa,Nikos Pantazis,Styliani I. Kokori,Maria G Tektonidou,Despina G. Contopoulos-Ioannidis,Joseph Lau +7 more
TL;DR: Despite good correlation between randomized trials and nonrandomized studies-in particular, prospective studies-discrepancies beyond chance do occur and differences in estimated magnitude of treatment effect are very common.
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Genetic associations in large versus small studies: an empirical assessment.
John P. A. Ioannidis,John P. A. Ioannidis,John P. A. Ioannidis,Thomas A Trikalinos,Thomas A Trikalinos,Evangelia E. Ntzani,Despina G. Contopoulos-Ioannidis,Despina G. Contopoulos-Ioannidis +7 more
TL;DR: How often large studies arrive at different conclusions than smaller studies is assessed, and whether this situation arises more frequently when findings of first published studies disagree with those of subsequent research is assessed.
Journal ArticleDOI
Standard 6: Age Groups for Pediatric Trials
Katrina Williams,Denise Thomson,Iva Seto,Despina G. Contopoulos-Ioannidis,John P. A. Ioannidis,Sarah Curtis,Evelyn Constantin,Gitanjali Batmanabane,Lisa Hartling,Terry P. Klassen +9 more
TL;DR: In this study, 128 meta-analyses from Cochrane reviews, containing data on at least 1 adult and 1 pediatric randomized controlled trial (RCT) with a binary primary efficacy outcome, were reviewed and it was found that in all except 1 case, the 95% confidence intervals could not exclude a relative difference in treatment efficacy between adults and children of >20%.
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Translation of highly promising basic science research into clinical applications
TL;DR: In this paper, the authors evaluated the predictors of and time taken for the translation of highly promising basic research into clinical experimentation and use and identified 101 articles, published between 1979 and 1983 in six major basic science journals, which clearly stated that the technology studied had novel therapeutic or preventive promises.