Dexi Yang

TL;DR: Overall, highly substituted heterocycles that contain three stereogenic centers and up to four fused rings can be accessed in two steps from relatively simple coupling partners.

TL;DR: Empirical models are proposed that are consistent with the observed stereochemical course of these coupling reactions en route to chiral homoallylic amines possessing di- or trisubstituted alkenes and anti- or syn- relative stereochemistry at the allylic and homoALLYlic positions.

TL;DR: Overall, the synthesis of alkaloid (-)-205B is asymmetric, concise, and highly stereoselective- features which point to the potential future utility of these chemical methods in natural product synthesis and medicinal chemistry.

TL;DR: A convergent and stereodivergent pathway to highly substituted 1-aza-7-oxabicyclo[2.2.1]heptanes is described, providing a convenient entry to densely functionalized homoallylic nitrones whose intramolecular annulation can be controlled to deliver one of two distinct heterocyclic skeletons, each with ≥20:1 stereoselection.

TL;DR: Free radical cyclization of 4 and 7 gave the expectedcyclization-reduction products along with considerable amounts of products derived from a cyclization-atom transfer-secondary cyclization process, along with two approaches to avoiding these unexpected products.