Dhiman Chatterjee

Bio: Dhiman Chatterjee is an academic researcher. The author has contributed to research in topics: Microbubbles & Sound pressure. The author has an hindex of 1, co-authored 1 publications receiving 2 citations.

The role of encapsulated microbubbles in the diagnosis of stenosis in arteries

Abstract: Numerical modelling of sound scattered by ultrasound contrast agent bubbles in arteries is presented. Nonlinear dynamics of an encapsulated microbubble coupled with transmission of sound through liquid-filled flexible tubing is developed. Based on the frequency response, a normal artery can be distinguished from that of a stenosed artery. Effects of parameters like incident pressure amplitude, driving frequency and degree of stenosis are studied. It is further found that the effect of variable pressure produced by blood flow does not have a significant effect on the observed sound pressure levels.

Artificial intelligence and guidance of medicine in the bubble.

Abstract: Microbubbles are nanosized gas-filled bubbles. They are used in clinical diagnostics, in medical imaging, as contrast agents in ultrasound imaging, and as transporters for targeted drug delivery. They can also be used to treat thrombosis, neoplastic diseases, open arteries and vascular plaques and for localized transport of chemotherapies in cancer patients. Microbubbles can be filled with any type of therapeutics, cure agents, growth factors, extracellular vesicles, exosomes, miRNAs, and drugs. Microbubbles protect their cargo from immune attack because of their specialized encapsulated shell composed of lipid and protein. Filled with curative medicine, they could effectively circulate through the whole body safely and efficiently to reach the target area. The advanced bubble-based drug-delivery system, integrated with artificial intelligence for guidance, holds great promise for the targeted delivery of drugs and medicines.

The Effect of Oxidation on the Mechanical Response of Isolated Elastin and Aorta

Abstract: Oxidation of aorta by hydroxyl radicals produces structural changes in arterial proteins like elastin and collagen, which results in change in the mechanical response of aorta. In this paper, with a view to understand the effect of oxidation on the mechanical behavior of aorta and isolated elastin, a thermodynamically consistent constitutive model is developed within the framework of mixture theory to describe the changes in aorta and isolated elastin with oxidation. The model is then studied under uniaxial extension using experimental data from literature.