Di Guo

Bio: Di Guo is an academic researcher from Xiamen University of Technology. The author has contributed to research in topics: Compressed sensing & Iterative reconstruction. The author has an hindex of 22, co-authored 86 publications receiving 2071 citations. Previous affiliations of Di Guo include Chinese Ministry of Education & Xiamen University.

Convolutional Neural Networks-Based MRI Image Analysis for the Alzheimer’s Disease Prediction From Mild Cognitive Impairment

Abstract: Mild cognitive impairment (MCI) is the prodromal stage of Alzheimer's disease (AD). Identifying MCI subjects who are at high risk of converting to AD is crucial for effective treatments. In this study, a deep learning approach based on convolutional neural networks (CNN), is designed to accurately predict MCI-to-AD conversion with magnetic resonance imaging (MRI) data. First, MRI images are prepared with age-correction and other processing. Second, local patches, which are assembled into 2.5 dimensions, are extracted from these images. Then, the patches from AD and normal controls (NC) are used to train a CNN to identify deep learning features of MCI subjects. After that, structural brain image features are mined with FreeSurfer to assist CNN. Finally, both types of features are fed into an extreme learning machine classifier to predict the AD conversion. The proposed approach is validated on the standardized MRI datasets from the Alzheimer's Disease Neuroimaging Initiative (ADNI) project. This approach achieves an accuracy of 79.9% and an area under the receiver operating characteristic curve (AUC) of 86.1% in leave-one-out cross validations. Compared with other state-of-the-art methods, the proposed one outperforms others with higher accuracy and AUC, while keeping a good balance between the sensitivity and specificity. Results demonstrate great potentials of the proposed CNN-based approach for the prediction of MCI-to-AD conversion with solely MRI data. Age correction and assisted structural brain image features can boost the prediction performance of CNN.

Fast Multiclass Dictionaries Learning With Geometrical Directions in MRI Reconstruction

Abstract: Objective: Improve the reconstructed image with fast and multiclass dictionaries learning when magnetic resonance imaging is accelerated by undersampling the k-space data. Methods: A fast orthogonal dictionary learning method is introduced into magnetic resonance image reconstruction to provide adaptive sparse representation of images. To enhance the sparsity, image is divided into classified patches according to the same geometrical direction and dictionary is trained within each class. A new sparse reconstruction model with the multiclass dictionaries is proposed and solved using a fast alternating direction method of multipliers. Results: Experiments on phantom and brain imaging data with acceleration factor up to 10 and various undersampling patterns are conducted. The proposed method is compared with state-of-the-art magnetic resonance image reconstruction methods. Conclusion: Artifacts are better suppressed and image edges are better preserved than the compared methods. Besides, the computation of the proposed approach is much faster than the typical K-SVD dictionary learning method in magnetic resonance image reconstruction. Significance: The proposed method can be exploited in undersampled magnetic resonance imaging to reduce data acquisition time and reconstruct images with better image quality.

Iterative thresholding compressed sensing MRI based on contourlet transform

Abstract: Reducing the acquisition time is important for clinical magnetic resonance imaging (MRI). Compressed sensing has recently emerged as a theoretical foundation for the reconstruction of magnetic resonance images from undersampled k-space measurements, assuming those images are sparse in a certain transform domain. However, most real-world signals are compressible rather than exactly sparse. For example, the commonly used two-dimensional wavelet for compressed sensing MRI (CS-MRI) does not sparsely represent curves and edges. In this article, we introduce a geometric image transform, the contourlet, to overcome this shortage. In addition, the improved redundancy provided by the contourlet can successfully suppress the pseudo-Gibbs phenomenon, a tiresome artefact produced by undersampling of k-space, around the singularities of images. For numerical calculation, a simple but effective iterative thresholding algorithm is employed to solve l 1 norm optimization for CS-MRI. Considering the recovered information ...

MR Image Reconstruction From Highly Undersampled k-Space Data by Dictionary Learning

Abstract: Compressed sensing (CS) utilizes the sparsity of magnetic resonance (MR) images to enable accurate reconstruction from undersampled k-space data. Recent CS methods have employed analytical sparsifying transforms such as wavelets, curvelets, and finite differences. In this paper, we propose a novel framework for adaptively learning the sparsifying transform (dictionary), and reconstructing the image simultaneously from highly undersampled k-space data. The sparsity in this framework is enforced on overlapping image patches emphasizing local structure. Moreover, the dictionary is adapted to the particular image instance thereby favoring better sparsities and consequently much higher undersampling rates. The proposed alternating reconstruction algorithm learns the sparsifying dictionary, and uses it to remove aliasing and noise in one step, and subsequently restores and fills-in the k-space data in the other step. Numerical experiments are conducted on MR images and on real MR data of several anatomies with a variety of sampling schemes. The results demonstrate dramatic improvements on the order of 4-18 dB in reconstruction error and doubling of the acceptable undersampling factor using the proposed adaptive dictionary as compared to previous CS methods. These improvements persist over a wide range of practical data signal-to-noise ratios, without any parameter tuning.

Deep ADMM-Net for compressive sensing MRI

Abstract: Compressive Sensing (CS) is an effective approach for fast Magnetic Resonance Imaging (MRI). It aims at reconstructing MR image from a small number of under-sampled data in k-space, and accelerating the data acquisition in MRI. To improve the current MRI system in reconstruction accuracy and computational speed, in this paper, we propose a novel deep architecture, dubbed ADMM-Net. ADMM-Net is defined over a data flow graph, which is derived from the iterative procedures in Alternating Direction Method of Multipliers (ADMM) algorithm for optimizing a CS-based MRI model. In the training phase, all parameters of the net, e.g., image transforms, shrinkage functions, etc., are discriminatively trained end-to-end using L-BFGS algorithm. In the testing phase, it has computational overhead similar to ADMM but uses optimized parameters learned from the training data for CS-based reconstruction task. Experiments on MRI image reconstruction under different sampling ratios in k-space demonstrate that it significantly improves the baseline ADMM algorithm and achieves high reconstruction accuracies with fast computational speed.

DAGAN: Deep De-Aliasing Generative Adversarial Networks for Fast Compressed Sensing MRI Reconstruction

Abstract: Compressed sensing magnetic resonance imaging (CS-MRI) enables fast acquisition, which is highly desirable for numerous clinical applications. This can not only reduce the scanning cost and ease patient burden, but also potentially reduce motion artefacts and the effect of contrast washout, thus yielding better image quality. Different from parallel imaging-based fast MRI, which utilizes multiple coils to simultaneously receive MR signals, CS-MRI breaks the Nyquist–Shannon sampling barrier to reconstruct MRI images with much less required raw data. This paper provides a deep learning-based strategy for reconstruction of CS-MRI, and bridges a substantial gap between conventional non-learning methods working only on data from a single image, and prior knowledge from large training data sets. In particular, a novel conditional Generative Adversarial Networks-based model (DAGAN)-based model is proposed to reconstruct CS-MRI. In our DAGAN architecture, we have designed a refinement learning method to stabilize our U-Net based generator, which provides an end-to-end network to reduce aliasing artefacts. To better preserve texture and edges in the reconstruction, we have coupled the adversarial loss with an innovative content loss. In addition, we incorporate frequency-domain information to enforce similarity in both the image and frequency domains. We have performed comprehensive comparison studies with both conventional CS-MRI reconstruction methods and newly investigated deep learning approaches. Compared with these methods, our DAGAN method provides superior reconstruction with preserved perceptual image details. Furthermore, each image is reconstructed in about 5 ms, which is suitable for real-time processing.