D
Diana Behrens
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 18
Citations - 376
Diana Behrens is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 8, co-authored 17 publications receiving 303 citations.
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Journal ArticleDOI
The nerve growth factor receptor CD271 is crucial to maintain tumorigenicity and stem-like properties of melanoma cells.
Torben Redmer,Yvonne Welte,Diana Behrens,Iduna Fichtner,Dorothea Przybilla,Wasco Wruck,Marie-Laure Yaspo,Hans Lehrach,Reinhold Schäfer,Christian R. A. Regenbrecht +9 more
TL;DR: A genome-wide expression profiling and gene-set enrichment analysis revealed novel connections of CD271 with melanoma-associated genes like CD133 and points to a neural crest stem cell (NCSC) signature lost upon CD271 knock-down.
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Effect of sialyl Lewis X-glycoliposomes on the inhibition of E-selectin-mediated tumour cell adhesion in vitro
TL;DR: S Sterically stabilised liposomes with the ligand at the terminal end of the polyethylene chain were the most effective inhibitors in all three assays and inhibited the adhesion of HT29 colon- and Lewis lung (LL) carcinoma cells by about 60-80%.
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Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo.
Martin Michaelis,Iduna Fichtner,Diana Behrens,Wolfram Haider,Florian Rothweiler,Andreas Mack,Jaroslav Cinatl,Hans Wilhelm Doerr,Jindrich Cinatl +8 more
TL;DR: Nanomolar concentrations of bortezomib inhibited the cell cycle and induced apoptosis in chemosensitive as well as in chemoresistant cell lines and inhibited vessel formation in neuroblastoma xenografts.
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Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology.
David Osuna de la Peña,David Osuna de la Peña,Sara Trabulo,Estelle Collin,Ying Liu,Shreya Sharma,Shreya Sharma,Marianthi Tatari,Diana Behrens,Mert Erkan,Rita T. Lawlor,Aldo Scarpa,Christopher Heeschen,Alvaro Mata,Daniela Loessner +14 more
TL;DR: In this article, the authors developed a more comprehensive and highly tuneable ex vivo model of pancreatic ductal adenocarcinoma (PDAC) based on the 3D co-assembly of peptide amphiphiles (PAs) with custom ECM components (PA-ECM).
Journal ArticleDOI
The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Johanna Grinat,Julian Heuberger,Julian Heuberger,Ramon Vidal,Neha Goveas,Frauke Kosel,Antoni Berenguer-Llergo,Andrea Kranz,Annika Wulf-Goldenberg,Diana Behrens,Balint Melcher,Sascha Sauer,Michael Vieth,Eduard Batlle,A. Francis Stewart,Walter Birchmeier +15 more
TL;DR: The results demonstrate that Mll1 is an essential epigenetic regulator of Wnt/β-catenin-induced intestinal tumorigenesis and cancer stemness.