Diana Constanza Plazas Hernández

Bio: Diana Constanza Plazas Hernández is an academic researcher from National University of Colombia. The author has contributed to research in topics: Cumulative dose & Prospective cohort study. The author has an hindex of 1, co-authored 2 publications receiving 24 citations.

Early-onset Cardiotoxicity assessment related to anthracycline in children with leukemia. A Prospective Study

Abstract: Background Acute leukemias are the most frequent malignancies in children. Advances in treatment have improved the overall survival to 80%. Almost 10% of children with cancer develop clinical cardiac toxicity. Total anthracycline cumulative dose is a risk factor for early-onset cardiotoxicity. Objective To describe the incidence of early-onset cardiotoxicity in children with acute leukemia treated with chemotherapy. Methods A prospective descriptive study of patients >1 y and Results 94 patients with acute lymphoblastic leukemia and 18 with acute myeloid leukemia were included. 20 patients (17.9%) developed early-onset cardiotoxicity. Statistically significant data was seen after anthracycline dose >150 mg/m2, between the first echocardiographic evaluation and posterior analyses in the left ventricular fraction ejection with Teicholz p 0.05, Simpson p 0.018 and GLS p 0.004. In this study, there was no relation between blood biomarkers and cardiotoxicity. Conclusions Cancer therapeutic-related cardiac dysfunction is related to anthracycline cumulative dose. In this study, echocardiographic follow-up was useful to predict risk factors for early cardiac dysfunction.

Model-based tuning approach for multi-band power system stabilisers PSS4B using an improved modal performance index

Abstract: Multi-band power system stabilisers (MB-PSSs) PSS4B (IEEE standard 421.5-2005) are advanced power system damping controllers that have evident advantages over conventional PSSs in damping low-frequency oscillatory modes. However, finding optimal settings for such controllers is challenging due to the increased complexity of the PSS4B structure. This study describes a methodology for MB-PSS parameter optimisation based on an improved modal performance index as a measure of the controller's stabilising effect. The tuning problem is formulated as a non-linear constrained optimisation search method: proposed modal performance index is chosen as an objective function to be minimised, while properly selected constraints ensure stability of the closed-loop system and robustness of the proposed design. The methodology is demonstrated on a benchmark system that is based on an existing network. Comparative analysis between the MB-PSSs with optimised settings and speed-based PSS1A-type stabilisers designed using the conventional methods show the practicality and effectiveness of the proposed methodology. The implemented approach has an advantage of being scalable and suitable for the model-based tuning of feedback controller of general structure. Additionally, several performance metrics and non-linear simulations in the ElectroMagnetic Transient Program (EMTP) software confirm superior characteristics of PSS4B.