Diana Hernandez

TL;DR: A trans-species aneuploid mouse line that stably transmits a freely segregating, almost complete human chromosome 21 (Hsa21) is generated, which is a model of trisomy 21, which manifests as Down syndrome in humans and has phenotypic alterations in behavior, synaptic plasticity, cerebellar neuronal number, heart development, and mandible size that relate to human DS.

TL;DR: In this paper, the authors reviewed and updated current knowledge of the structure and expression profiles of these genes and of their mouse counterparts and to determine, via a bioinformatics approach, whether other flavin-containing monooxygenase (FMO) genes are present in the human and mouse genomes.

TL;DR: RNase protection assays showed that the most abundant isoform in newborn liver, lung, kidney and brain, and in adult lung and kidney is FMO1, but in adult liver FMO5 is present in greatest amounts.

TL;DR: A human FMO3 mutation database was created using MuStar, a locus‐specific database system for maintaining data about allelic variants and distributing these via the World Wide Web, and is accessible on the World wide Web via the URL http://human‐fmo3.ucl.ac.uk/Human_FMO3.

TL;DR: Mimicking physiological O(2) tension is a favorable condition for the efficient generation of RPCs from both hiPSCs and hESCs, indicating that efficient differentiation of retinal cells from human pluripotent stem cells remains a major challenge.