Metal-Free Multicomponent Syntheses of Pyridines

Multicomponent domino reactions (MDRs) serve as a rapid and efficient tool for the synthesis of versatile heterocycles, particularly those containing structural diversity and complexity, by a one-pot operation. These reactions can dramatically reduce the generation of chemical wastes, costs of starting materials, and the use of energy and manpower. Moreover, the reaction period can be substantially shortened. This Review covers recent advances on multicomponent domino reactions for the construction of five-, six-, and seven-membered heterocyclic skeletons and their multicyclic derivatives.

Multicomponent Reactions for the Synthesis of Heterocycles

A practical and green approach for the one-pot multicomponent synthesis of tetraheterocyclic benzimidazolo[2,3-b]quinazolinones has been described via the condensation of 2-aminobenzimidazole or 2-...

Synthesis of Benzimidazolo[2,3-b]quinazolinone Derivatives via a One-pot Multicomponent Reaction Promoted by a Chitosan-based Composite Magnetic Nanocatalyst

Ultrasonic assisted synergetic green synthesis of polycyclic imidazo(thiazolo)pyrimidines by using Fe3O4@clay core-shell

Because of the significant role in biological processes in living cells and the diverse types of physiological activities, heterocyclic compounds are in focus of intense investigations by academic and applied-oriented chemists. Considerably, a scientific renaissance of heterocycles during the last decades is closely related to the development of multicomponent approaches to their synthesis. Multicomponent methodology fundamentally different from two-component or sequential processes together with other innovative synthetic methods like microwave- and ultrasonic- assisted reactions offer some new possibilities in constructing heterocyclic systems with high level of molecular diversity and complexity. An overview of known multicomponent heterocyclizations using aminoazoles as a key reagent and their rich synthetic potential for obtaining five-, six-, and seven-membered heterocycles is presented. A special attention is paid to the tuning of chemo- and regio- and positional selectivity of some reactions as well as to the application of nonclassical activation methods based on microwave and ultrasonic irradiation.

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Aminoazoles as Key Reagents in Multicomponent Heterocyclizations

Green and high efficient synthesis of triaza‐benzo[b]fluoren‐6‐one derivatives in water under microwave irradiation

A green and efficient synthesis of furo[3,4-e]pyrazolo[3,4-b]-pyridine derivatives in water under microwave irradiation without catalyst

An efficient microwave‐assisted synthesis furo[3,4‐b]‐[4,7] phenanthroline and indeno[2,1‐b][4,7]phenanthroline derivatives in water

An unexpected and efficient synthesis of novel open-chain derivatives of bistetronic acid has been successfully achieved in glyclol under microwave irradiation (MW). This method has the prominent advantages of short reaction time, high yield, operational simplicity as well as environmental friendliness.

An Unexpected and Efficient Synthesis of Open‐chain Derivatives of Bistetronic Acid under Microwave Irradiation

In the mol­ecule of the title compound, C21H21N3O3, the pyrimidine ring adopts a boat conformation. Inter­molecular N—H⋯N hydrogen bonds link the independent mol­ecules into dimers, which may be effective in stabilizing the crystal structure.

Dianxiang Zhou

Papers

Green and high efficient synthesis of triaza‐benzo[b]fluoren‐6‐one derivatives in water under microwave irradiation

A green and efficient synthesis of furo[3,4-e]pyrazolo[3,4-b]-pyridine derivatives in water under microwave irradiation without catalyst

An efficient microwave‐assisted synthesis furo[3,4‐b]‐[4,7] phenanthroline and indeno[2,1‐b][4,7]phenanthroline derivatives in water

An Unexpected and Efficient Synthesis of Open‐chain Derivatives of Bistetronic Acid under Microwave Irradiation

Ethyl 4‐(4‐methoxyphenyl)‐2‐methyl‐1,4‐dihydrobenzo[4,5]imidazo[1,2‐a]pyrimidine‐3‐carboxylate

Dianxiang Zhou

Papers

Green and high efficient synthesis of triaza‐benzo[b]fluoren‐6‐one derivatives in water under microwave irradiation

A green and efficient synthesis of furo[3,4-e]pyrazolo[3,4-b]-pyridine derivatives in water under microwave irradiation without catalyst

An efficient microwave‐assisted synthesis furo[3,4‐b]‐[4,7] phenanthroline and indeno[2,1‐b][4,7]phenanthroline derivatives in water

An Unexpected and Efficient Synthesis of Open‐chain Derivatives of Bistetronic Acid under Microwave Irradiation

Ethyl 4‐(4‐methoxy­phen­yl)‐2‐methyl‐1,4‐dihydro­benzo[4,5]imidazo[1,2‐a]pyrimidine‐3‐carboxyl­ate

Ethyl 4‐(4‐methoxyphenyl)‐2‐methyl‐1,4‐dihydrobenzo[4,5]imidazo[1,2‐a]pyrimidine‐3‐carboxylate