D
Diederick E. Grobbee
Researcher at Utrecht University
Publications - 1108
Citations - 136069
Diederick E. Grobbee is an academic researcher from Utrecht University. The author has contributed to research in topics: Population & Risk factor. The author has an hindex of 155, co-authored 1051 publications receiving 122748 citations. Previous affiliations of Diederick E. Grobbee include National Heart Foundation of Australia & Radboud University Nijmegen Medical Centre.
Papers
More filters
Journal ArticleDOI
Asymmetrical distribution of atherosclerosis in the carotid artery: identical patterns across age, race, and gender.
Parvin Tajik,Parvin Tajik,Rudy Meijer,Raphaël Duivenvoorden,Sanne A.E. Peters,John J.P. Kastelein,Frank J. L. Visseren,John R. Crouse,Mike K. Palmer,Joel S. Raichlen,Diederick E. Grobbee,Michiel L. Bots +11 more
TL;DR: The asymmetrical helix-like distribution of atherosclerosis in the carotid arteries is confirmed and the evidence is expanded by showing that the atherosclerotic configuration is similar across populations with different vascular risks and across gender, age, and race.
Journal ArticleDOI
Ethics of Informed Consent for Pragmatic Trials with New Interventions
Shona Kalkman,Scott Y. H. Kim,Ghislaine J. M. W. van Thiel,Diederick E. Grobbee,Johannes J. M. van Delden +4 more
TL;DR: This article presents an analysis of the ethical issues involved in informed consent for EPTs, in light of the generally recognized concern that traditional ethical rules governing randomized clinical trials, such as lengthy informed consent procedures, could threaten the "real world" nature of such trials.
Journal ArticleDOI
Application of a diagnostic decision rule in children with meningeal signs: a cost-minimization study
Rianne Oostenbrink,Jan B. Oostenbrink,Karel G.M. Moons,Gerarda Derksen-Lubsen,Diederick E. Grobbee,W. Ken Redekop,Henriëtte A. Moll +6 more
TL;DR: A diagnostic decision rule for children with meningeal signs has the potential to improve the appropriate use of medical resources, to be cost-effective, and to ascertain the absence of bacterial meningitis earlier.
Journal ArticleDOI
Optimizing trial design in pharmacogenetics research: comparing a fixed parallel group, group sequential, and adaptive selection design on sample size requirements
Ruud Boessen,Frederieke H. van der Baan,Rolf H.H. Groenwold,Antoine C. G. Egberts,Olaf H. Klungel,Diederick E. Grobbee,Mirjam J. Knol,Kit C.B. Roes +7 more
TL;DR: This study compared sample size requirements for fixed parallel group, group sequential, and adaptive selection designs with equal overall power and control of the family‐wise type I error rate to find the most efficient two‐stage clinical trial designs.
Journal ArticleDOI
Niet-herkend hartfalen bij oudere patiënten met chronisch obstructieve longziekte
Frans H. Rutten,Maarten-Jan M. Cramer,Diederick E. Grobbee,Alfred P E Sachs,J. H. Kirkels,Jan-Willem J. Lammers,Arno W. Hoes +6 more
TL;DR: Oudere patiënten met een huisartsdiagnose COPD of chronische bronchitis wordt hartfalen vaak niet herkend, werden uitgebreid onderzocht door middel van anamnese (met voorgeschiedenis), lichamelijk onderzoek, longfoto, elektrocardiografie, bloedonderzoek