D
Diederick E. Grobbee
Researcher at Utrecht University
Publications - 1108
Citations - 136069
Diederick E. Grobbee is an academic researcher from Utrecht University. The author has contributed to research in topics: Population & Risk factor. The author has an hindex of 155, co-authored 1051 publications receiving 122748 citations. Previous affiliations of Diederick E. Grobbee include National Heart Foundation of Australia & Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Trends in the prevalence of hypertension, antihypertensive therapy, and left ventricular hypertrophy from 1950 to 1989.
Arend Mosterd,Ralph B. D'Agostino,Halit Silbershatz,Pamela A. Sytkowski,William B. Kannel,Diederick E. Grobbee,Daniel Levy +6 more
TL;DR: The notion that the increasing use of antihypertensive medication has resulted in a reduced prevalence of high blood pressure and a concomitant decline in left ventricular hypertrophy in the general population is supported.
Journal ArticleDOI
Effect of Moderate Alcohol Consumption on Adiponectin, Tumor Necrosis Factor-α, and Insulin Sensitivity
Aafje Sierksma,Hamina J. Patel,Noriyuki Ouchi,Shinji Kihara,Tohru Funahashi,Robert J. Heine,Diederick E. Grobbee,Cornelis Kluft,H.F.J. Hendriks +8 more
TL;DR: Moderate alcohol consumption improved insulin sensitivity in relatively insulin-resistant middle-aged men, an effect that may be mediated through alcohol-induced increases in adiponectin.
Journal ArticleDOI
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
Lisette Stolk,John R. B. Perry,John R. B. Perry,Daniel I. Chasman,Chunyan He,Massimo Mangino,Patrick Sulem,Maja Barbalić,Linda Broer,Enda M. Byrne,Florian Ernst,Tmu Esko,Nora Franceschini,Daniel F. Gudbjartsson,Jouke-Jan Hottenga,Peter Kraft,Peter Kraft,Patrick F. McArdle,Eleonora Porcu,So-Youn Shin,Albert V. Smith,Sophie H. Van Wingerden,Guangju Zhai,Guangju Zhai,Wei V. Zhuang,Eva Albrecht,Behrooz Z. Alizadeh,Thor Aspelund,Stefania Bandinelli,Lovorka Barać Lauc,Jacques S. Beckmann,Mladen Boban,Eric Boerwinkle,Frank J.M. Broekmans,Andrea Burri,Harry Campbell,Stephen J. Chanock,Constance Chen,Marilyn C. Cornelis,Tanguy Corre,Andrea D. Coviello,Pio D'Adamo,Gail Davies,Ulf de Faire,Eco J. C. de Geus,Ian J. Deary,George Dedoussis,Panagiotis Deloukas,Shah Ebrahim,Gudny Eiriksdottir,Valur Emilsson,Johan G. Eriksson,Bart C.J.M. Fauser,Liana Ferreli,Luigi Ferrucci,Krista Fischer,Aaron R. Folsom,Melissa E. Garcia,Paolo Gasparini,Christian Gieger,Nicole L. Glazer,Diederick E. Grobbee,Per Hall,Toomas Haller,Susan E. Hankinson,Merli Hass,Caroline Hayward,Andrew C. Heath,Albert Hofman,Erik Ingelsson,A. Cecile J.W. Janssens,Andrew D. Johnson,David Karasik,David Karasik,Sharon L.R. Kardia,Jules J. Keyzer,Douglas P. Kiel,Douglas P. Kiel,Ivana Kolcic,Z. Kutalik,Z. Kutalik,Jari Lahti,Sandra Lai,Triin Laisk,Joop S.E. Laven,Debbie A Lawlor,Jianjun Liu,Lorna M. Lopez,Yvonne V. Louwers,Patrik K. E. Magnusson,Mara Marongiu,Nicholas G. Martin,Irena Martinović Klarić,Corrado Masciullo,Barbara McKnight,Sarah E. Medland,David Melzer,Vincent Mooser,Pau Navarro,Anne B. Newman,Dale R. Nyholt,N. Charlotte Onland-Moret,Aarno Palotie,Guillaume Paré,Guillaume Paré,Alexander N. Parker,Nancy L. Pedersen,Petra H.M. Peeters,Giorgio Pistis,Andrew S. Plump,Ozren Polasek,Victor J M Pop,Bruce M. Psaty,Bruce M. Psaty,Katri R Currency Signikkönen,Emil Rehnberg,Jerome I. Rotter,Igor Rudan,Igor Rudan,Cinzia Sala,Andres Salumets,Angelo Scuteri,Andrew B. Singleton,Jennifer A. Smith,Harold Snieder,Nicole Soranzo,Nicole Soranzo,Simon N. Stacey,John M. Starr,Maria G. Stathopoulou,Kathleen Stirrups,Ronald P. Stolk,Unnur Styrkarsdottir,Yan V. Sun,Albert Tenesa,Barbara Thorand,Daniela Toniolo,Laufey Tryggvadottir,Kim Tsui,Sheila Ulivi,Rob M. van Dam,Rob M. van Dam,Yvonne T. van der Schouw,Carla H. van Gils,Peter Van Nierop,Jacqueline M. Vink,Peter M. Visscher,Peter M. Visscher,Marlies Voorhuis,Gérard Waeber,Henri Wallaschofski,H.-Erich Wichmann,Elisabeth Widen,Colette J M Wijnands-van Gent,Gonneke Willemsen,James F. Wilson,Bruce H. R. Wolffenbuttel,Alan F. Wright,Laura M. Yerges-Armstrong,Tatijana Zemunik,Lina Zgaga,Lina Zgaga,M. Carola Zillikens,Marek Zygmunt,Alice M. Arnold,Dorret I. Boomsma,Julie E. Buring,Laura Crisponi,Ellen W. Demerath,Ellen W. Demerath,Vilmundur Gudnason,Tamara B. Harris,Frank B. Hu,David J. Hunter,David J. Hunter,Lenore J. Launer,Andres Metspalu,Grant W. Montgomery,Ben A. Oostra,Paul M. Ridker,Serena Sanna,David Schlessinger,Tim D. Spector,Kari Stefansson,Kari Stefansson,Elizabeth A. Streeten,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Manuela Uda,André G. Uitterlinden,Cornelia M. van Duijn,Henry Völzke,Anna Murray,Anna Murray,Joanne M. Murabito,Jenny A. Visser,Jenny A. Visser,Kathryn L. Lunetta,Kathryn L. Lunetta +198 more
TL;DR: A meta-analysis of 22 genome-wide association studies in 38,968 women of European descent identified 13 loci newly associated with age at natural menopause, including genes implicated in DNA repair, immune function and immune function.
Journal ArticleDOI
Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies
Judith S. Brand,Ingeborg van der Tweel,Diederick E. Grobbee,Marielle H. Emmelot-Vonk,Yvonne T. van der Schouw +4 more
TL;DR: In this paper, the authors conducted a meta-analysis of observational studies relating metabolic syndrome to determinants of testosterone status [total testosterone (TT), free testosterone (FT) and sex hormone binding globulin (SHBG).
Journal ArticleDOI
Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci
Richa Saxena,Richa Saxena,Clara C. Elbers,Clara C. Elbers,Yiran Guo,Inga Peter,Tom R. Gaunt,Jessica L. Mega,Matthew B. Lanktree,Archana Tare,Archana Tare,Berta Almoguera Castillo,Berta Almoguera Castillo,Yun Li,Toby Johnson,Marcel Bruinenberg,Diane Gilbert-Diamond,Ramakrishnan Rajagopalan,Benjamin F. Voight,Benjamin F. Voight,Ashok Balasubramanyam,John Barnard,Florianne Bauer,Jens Baumert,Tushar Bhangale,Bernhard O. Böhm,Peter S. Braund,Paul Burton,Hareesh R. Chandrupatla,Robert Clarke,Rhonda M. Cooper-DeHoff,Errol D. Crook,George Davey-Smith,Ian N. M. Day,Anthonius de Boer,Mark C.H. De Groot,Fotios Drenos,Jane F. Ferguson,Caroline S. Fox,Clement E. Furlong,Quince Gibson,Christian Gieger,Lisa A. Gilhuijs-Pederson,Joseph T. Glessner,Anuj Goel,Yan Gong,Struan F.A. Grant,Diederick E. Grobbee,Claire E. Hastie,Steve E. Humphries,Cecilia E. Kim,Mika Kivimäki,Marcus E. Kleber,Christa Meisinger,Meena Kumari,Taimour Y. Langaee,Debbie A Lawlor,Mingyao Li,Maximilian T. Lobmeyer,Anke-Hilse Maitland-van der Zee,Matthijs F.L. Meijs,Cliona Molony,David A. Morrow,Gurunathan Murugesan,Solomon K. Musani,Christopher P. Nelson,Stephen Newhouse,Jeffery R. O'Connell,Sandosh Padmanabhan,Jutta Palmen,Sanjey R. Patel,Carl J. Pepine,Mary Pettinger,Thomas S. Price,Suzanne Rafelt,Jane E. Ranchalis,Asif Rasheed,Elisabeth A. Rosenthal,Ingo Ruczinski,Sonia Shah,Haiqing Shen,Günther Silbernagel,Erin N. Smith,Annemieke W M Spijkerman,Alice Stanton,Michael W. Steffes,Barbara Thorand,Mieke D. Trip,Pim van der Harst,Daphne L. van der A,Erik P A Van Iperen,Jessica van Setten,Jana V. van Vliet-Ostaptchouk,Niek Verweij,Bruce H. R. Wolffenbuttel,Taylor Young,M. Hadi Zafarmand,Joseph M. Zmuda,Michael Boehnke,David Altshuler,David Altshuler,Mark I. McCarthy,W. H. Linda Kao,James S. Pankow,Thomas P. Cappola,Peter S. Sever,Neil R Poulter,Mark J. Caulfield,Anna F. Dominiczak,Denis C. Shields,Deepak L. Bhatt,Li Zhang,Sean P. Curtis,John Danesh,Juan P. Casas,Juan P. Casas,Yvonne T. van der Schouw,N. Charlotte Onland-Moret,Pieter A. Doevendans,Gerald W. Dorn,Martin Farrall,Garret A. FitzGerald,Anders Hamsten,Robert A. Hegele,Aroon D. Hingorani,Marten H. Hofker,Gordon S. Huggins,Thomas Illig,Gail P. Jarvik,Julie A. Johnson,Olaf H. Klungel,William C. Knowler,Wolfgang Koenig,Winfried März,James B. Meigs,Olle Melander,Patricia B. Munroe,Braxton D. Mitchell,S. J. Bielinski,Daniel J. Rader,Muredach P. Reilly,Stephen S. Rich,Jerome I. Rotter,Danish Saleheen,Nilesh J. Samani,Eric E. Schadt,Alan R. Shuldiner,Roy L. Silverstein,Kandice Kottke-Marchant,Philippa J. Talmud,Hugh Watkins,Folkert W. Asselbergs,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Jeanne M. McCaffery,Cisca Wijmenga,Marc S. Sabatine,James G. Wilson,Alexander P. Reiner,Donald W. Bowden,Hakon Hakonarson,David S. Siscovick,Brendan J. Keating +163 more
TL;DR: Large-scale meta-analysis involving a dense gene-centric approach has uncovered additional loci and variants that contribute to type 2 diabetes risk and suggests substantial overlap of T2D association signals across multiple ethnic groups.