D
Diego H. Castrillon
Researcher at University of Texas Southwestern Medical Center
Publications - 116
Citations - 16656
Diego H. Castrillon is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Cancer & Endometrial cancer. The author has an hindex of 54, co-authored 108 publications receiving 15087 citations. Previous affiliations of Diego H. Castrillon include Johns Hopkins University & Harvard University.
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Journal ArticleDOI
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Zuzana Tothova,Zuzana Tothova,Ramya Kollipara,Brian J. P. Huntly,Benjamin H. Lee,Benjamin H. Lee,Diego H. Castrillon,Dana E. Cullen,Dana E. Cullen,Elizabeth P. McDowell,Elizabeth P. McDowell,Suzan Lazo-Kallanian,Ifor R. Williams,Christopher Sears,Scott A. Armstrong,Emmanuelle Passegué,Ronald A. DePinho,D. Gary Gilliland,D. Gary Gilliland +18 more
TL;DR: FoxO proteins play essential roles in the response to physiologic oxidative stress and thereby mediate quiescence and enhanced survival in the HSC compartment, a function that is required for its long-term regenerative potential.
Journal ArticleDOI
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
Jihye Paik,Ramya Kollipara,Gerald C. Chu,Hongkai Ji,Yonghong Xiao,Zhihu Ding,Lili Miao,Zuzana Tothova,James W. Horner,Daniel R. Carrasco,Shan Jiang,D. Gary Gilliland,Lynda Chin,Wing Hung Wong,Diego H. Castrillon,Diego H. Castrillon,Ronald A. DePinho +16 more
TL;DR: The role of the mammalian FoxO transcription factor family (FoxO1, FoxO3, and FoxO4) in PI3K-AKT signaling appears to be an obligate event in the development of cancer.
Journal ArticleDOI
LKB1 modulates lung cancer differentiation and metastasis
Hongbin Ji,Matthew R. Ramsey,D. Neil Hayes,Cheng Fan,Kate McNamara,Piotr Kozlowski,Chad Torrice,Michael C. Wu,Takeshi Shimamura,Samanthi A. Perera,Mei-Chih Liang,Dongpo Cai,George N. Naumov,Lei Bao,Cristina Contreras,Danan Li,Liang Chen,Janakiraman Krishnamurthy,Jussi Koivunen,Lucian R. Chirieac,Robert F. Padera,Roderick T. Bronson,Neal I. Lindeman,David C. Christiani,Xihong Lin,Geoffrey I. Shapiro,Pasi A. Jänne,Bruce E. Johnson,Matthew Meyerson,David J. Kwiatkowski,Diego H. Castrillon,Nabeel Bardeesy,Norman E. Sharpless,Kwok-Kin Wong +33 more
TL;DR: LKB1 is established as a critical barrier to pulmonary tumorigenesis, controlling initiation, differentiation and metastasis in lung cancer, and expression profiling in human lung cancer cell lines and mouse lung tumours identified a variety of metastasis-promoting genes as targets of LKB1 repression.
Journal ArticleDOI
Suppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a
Diego H. Castrillon,Lili Miao,Ramya Kollipara,James W. Horner,Ronald A. DePinho,Ronald A. DePinho +5 more
TL;DR: It is shown that Foxo3a–/– female mice exhibit a distinctive ovarian phenotype of global follicular activation leading to oocyte death, early depletion of functional ovarian follicles, and secondary infertility, raising the possibility that accelerated follicular initiation plays a role in premature ovarian failure, a common cause of infertility and premature aging in women.
Journal ArticleDOI
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.
Norman E. Sharpless,Nabeel Bardeesy,Kee Ho Lee,Daniel R. Carrasco,Diego H. Castrillon,Andrew J. Aguirre,Emily A. Wu,James W. Horner,Ronald A. DePinho +8 more
TL;DR: The generation and characterization of a p16Ink4a-specific knockout mouse that retains normal p19Arf function are described, establishing that p 16Ink 4a, along with p19 Arf, functions as a tumour suppressor in mice.