D
Dieter Heindl
Researcher at Hoffmann-La Roche
Publications - 182
Citations - 1584
Dieter Heindl is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Nucleic acid & Oligonucleotide. The author has an hindex of 21, co-authored 182 publications receiving 1524 citations. Previous affiliations of Dieter Heindl include Ludwig Maximilian University of Munich & Roche Diagnostics.
Papers
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Journal ArticleDOI
The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture *
Klaus Klumpp,Vincent Leveque,Sophie Le Pogam,Han Ma,Wen-Rong Jiang,Hyunsoon Kang,Caroline Granycome,Margaret Singer,Carl Laxton,Julie Qi Hang,Keshab Sarma,David Bernard Smith,Dieter Heindl,Christopher John Hobbs,John Herbert Merrett,Julian Symons,Nick Cammack,Joseph A. Martin,Rene Devos,Isabel Najera +19 more
TL;DR: Hepatitis C virus (HCV) polymerase activity is essential for HCV replication and the corresponding 5′-triphosphate derivative (R1479-TP) is a potent inhibitor of native HCV replicase isolated from replicon cells and of recombinant HCV polymerase (NS5B)-mediated RNA synthesis activity.
Journal ArticleDOI
Gold nanostoves for microsecond DNA melting analysis.
Joachim Stehr,Calin Hrelescu,Ralph A. Sperling,Gunnar Raschke,Michael Wunderlich,Alfons Nichtl,Dieter Heindl,K. Kürzinger,Wolfgang J. Parak,Thomas A. Klar,Jochen Feldmann +10 more
TL;DR: It is shown that double-stranded DNA melts on a microsecond time scale that leads to a disintegration of the gold nanoparticle aggregates on a millisecond time scale, indicating a perfectly matching and a point-mutated DNA sequence can be clearly distinguished in less than one millisecond even in a 1:1 mixture of both targets.
Journal ArticleDOI
A Convergent Strategy for the Modification of Peptide Nucleic Acids: Novel Mismatch-Specific PNA-Hybridization Probes.
TL;DR: Coupling of nonnatural nucleobases to the orthogonally protected backbone 1 on the solid phase provided access to novel peptide nucleic acid (PNA) conjugates 2, which are difficult to synthesize by standard routes.
Patent
Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses
TL;DR: In this paper, a 7-substituted 7-deaza-8aza-2,6-diamino-purine bases were used for nucleic acid binding compounds.
Patent
Stable nad/nadh derivatives
TL;DR: In this article, the present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.