Dik C. van Gent

TL;DR: Interactions between both double-stranded break-repair pathways and other cellular processes, such as cell-cycle regulation and replication, are being unveiled.

TL;DR: This review aims to provide a foundational understanding of how the homologous recombination and non-homologous end joining pathways operate, and to demonstrate how a better understanding of these processes has advanced both the understanding of the underlying causes of cancer and the ability to innovate novel cancer treatment strategies.

TL;DR: Recent research on the Nijmegen breakage syndrome suggests a direct link between activation of cell-cycle checkpoints and DSB repair, and the biochemical activities of proteins involved in the two major D SB repair pathways, homologous recombination and DNA end-joining, are beginning to emerge.

TL;DR: It is suggested that a unified role for R/M in multiple aspects of DNA repair and chromosome metabolism is to provide a flexible, possibly dynamic, link between DNA ends.

TL;DR: This work shows that loss of REV7 in mouse and human cell lines re-establishes CTIP-dependent end resection of DSBs in BRCA1-deficient cells, leading to HR restoration and PARP inhibitor resistance, which is reversed by ATM kinase inhibition.