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Dileepa Diyagama
Researcher at Peter MacCallum Cancer Centre
Publications - 8
Citations - 1564
Dileepa Diyagama is an academic researcher from Peter MacCallum Cancer Centre. The author has contributed to research in topics: Genetically modified mouse & Cellular differentiation. The author has an hindex of 7, co-authored 8 publications receiving 1496 citations. Previous affiliations of Dileepa Diyagama include Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
A comparison of background correction methods for two-colour microarrays
Matthew E. Ritchie,Jeremy D. Silver,Alicia Oshlack,Melissa L. Holmes,Dileepa Diyagama,Andrew J. Holloway,Gordon K. Smyth +6 more
TL;DR: The model-based correction methods are shown to be markedly superior to the usual practice of subtracting local background estimates, and methods which stabilize the variances of the log-ratios along the intensity range perform the best.
Journal ArticleDOI
Empirical array quality weights in the analysis of microarray data
Matthew E. Ritchie,Dileepa Diyagama,Jody Neilson,Ryan van Laar,Alexander Dobrovic,Andrew J. Holloway,Gordon K. Smyth +6 more
TL;DR: A graduated approach to array quality is considered based on empirical reproducibility of the gene expression measures from replicate arrays, and allows poorer quality arrays, which would otherwise be discarded, to be included in an analysis.
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Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma
David Thomas,Sandra A Johnson,Natalie A. Sims,Melanie Trivett,John Slavin,Brian P. Rubin,Paul Waring,Grant A. McArthur,Carl R. Walkley,Andrew J. Holloway,Dileepa Diyagama,Jonathon E. Grim,Bruce E. Clurman,David D.L. Bowtell,Jong Seo Lee,Gabriel M. Gutierrez,Denise M. Piscopo,Shannon A. Carty,Philip W. Hinds +18 more
TL;DR: Physiologic coupling of osteoblast differentiation to cell cycle withdrawal is mediated through runx2 and p27KIP1, and these processes are disrupted in osteosarcoma.
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A Molecular Diagnostic Test for Distinguishing Lung Adenocarcinoma from Malignant Mesothelioma Using Cells Collected from Pleural Effusions
Andrew J. Holloway,Dileepa Diyagama,Kenneth Opeskin,Jenette Creaney,Bruce W. S. Robinson,Richard A. Lake,David D.L. Bowtell +6 more
TL;DR: A gene expression–based test is designed to classify the primary tumor causing a malignant pleural effusion, using cells collected from the effusion itself, and is able to distinguish between lung adenocarcinoma and mesothelioma in cells collection from Pleural effusions.
Journal ArticleDOI
Gene expression analysis in absence epilepsy using a monozygotic twin design
Ingo Helbig,Nicholas Matigian,Nicholas Matigian,Lata Vadlamudi,Kate M. Lawrence,Marta A. Bayly,Sharon M. Bain,Dileepa Diyagama,Ingrid E. Scheffer,Ingrid E. Scheffer,John C. Mulley,Andrew J. Holloway,Leanne M. Dibbens,Samuel F. Berkovic,Nicholas K. Hayward +14 more
TL;DR: The objective is to identify genes involved in idiopathic absence epilepsies by analyzing gene expression using a monozygotic (MZ) twin design.