Dimitra Papadimitriou

Bio: Dimitra Papadimitriou is an academic researcher from University of Patras. The author has contributed to research in topics: Corporate social responsibility & Medicine. The author has an hindex of 25, co-authored 81 publications receiving 1756 citations. Previous affiliations of Dimitra Papadimitriou include National and Kapodistrian University of Athens & University of Thessaly.

Destination Personality, Affective Image, and Behavioral Intentions in Domestic Urban Tourism

Abstract: The collective influence of destination personality and affective image on overall image formation of a domestic urban destination and subsequently its influence on tourists’ behavioral intentions were examined in this study. The sample consisted of 361 urban tourists and included both past visitors and nonvisitors of the urban destination under study. Data analysis confirmed the influential role of destination personality and affective image in the formation of overall destination image in both samples. In turn, overall image was a mediator of the relationships of destination personality and affective image with tourists’ behavioral intentions (i.e., intention to revisit the urban destination and intention to recommend the destination to others). Analysis of the data supported a two-factor solution of the destination personality construct, with the personality traits of sincerity and excitement emerging in the domestic urban context to influence past visitors’ and nonvisitors’ overall destination image p...

Destination Image Components and Word-of-Mouth Intentions in Urban Tourism A Multigroup Approach

Abstract: The purpose of this study was to explore differences among three distinct groups, namely local residents, past tourists, and prospective tourists, in their perceptions of cognitive, affective, and overall image of a city destination and their future behavior. Analysis of data generally confirmed previously established structural relationships of cognitive and affective image, overall destination image, and word-of-mouth intentions. However, differences were identified among the three groups in terms of their destination image perceptions and their behavioral intentions to engage in word-of-mouth communications. Specifically, residents who engaged in word-of-mouth were primarily influenced by the cognitive and affective destination image components, while tourists relied on overall image perceptions.

Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson’s disease

Abstract: α-Synuclein (αSyn) is the major gene linked to sporadic Parkinson’s disease (PD), whereas the G209A (p.A53T) αSyn mutation causes a familial form of PD characterized by early onset and a generally severe phenotype, including nonmotor manifestations. Here we generated de novo induced pluripotent stem cells (iPSCs) from patients harboring the p.A53T mutation and developed a robust model that captures PD pathogenic processes under basal conditions. iPSC-derived mutant neurons displayed novel disease-relevant phenotypes, including protein aggregation, compromised neuritic outgrowth, and contorted or fragmented axons with swollen varicosities containing αSyn and Tau. The identified neuropathological features closely resembled those in brains of p.A53T patients. Small molecules targeting αSyn reverted the degenerative phenotype under both basal and induced stress conditions, indicating a treatment strategy for PD and other synucleinopathies. Furthermore, mutant neurons showed disrupted synaptic connectivity and widespread transcriptional alterations in genes involved in synaptic signaling, a number of which have been previously linked to mental disorders, raising intriguing implications for potentially converging disease mechanisms.

A new mitochondrial DNA mutation in ND3 gene causing severe Leigh syndrome with early lethality.

Abstract: We describe a new mitochondrial DNA mutation in a male infant who presented clinical and magnetic resonance imaging features of Leigh syndrome and died at the age of 9 mo. The patient's development was reportedly normal in the first months of life. At the age of 5 mo, he presented severe generalized hypotonia, nystagmus, and absent eye contact. Laboratory examination showed increased lactate and pyruvate in both serum and cerebrospinal fluid. Brain magnetic resonance imaging revealed multiple necrotic lesions in the basal ganglia, brain stem, and thalamus. Muscle histopathology was unremarkable, whereas respiratory chain enzyme analysis revealed a severe complex I deficiency. The patient died after an acidotic coma at age 9 mo. Sequence analysis of the entire mtDNA disclosed a new T10158C mutation with variable tissue heteroplasm (muscle: 83%; blood: 48%). The mutation was undetectable in the blood of his unaffected mother. The transition changes a serine residue into a proline, in a highly conserved region of the NADH dehydrogenase subunit 3 (ND3). This is the first description of a mitochondrial ND3 gene in Leigh syndrome with early lethality.

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The iron cage revisited: Institutional isomorphism and collective rationality in organizational fields (Chinese Translation)

Abstract: What makes organizations so similar? We contend that the engine of rationalization and bureaucratization has moved from the competitive marketplace to the state and the professions. Once a set of organizations emerges as a field, a paradox arises: rational actors make their organizations increasingly similar as they try to change them. We describe three isomorphic processes-coercive, mimetic, and normative—leading to this outcome. We then specify hypotheses about the impact of resource centralization and dependency, goal ambiguity and technical uncertainty, and professionalization and structuration on isomorphic change. Finally, we suggest implications for theories of organizations and social change.