D
Dimitrios A. Pappas
Researcher at Columbia University
Publications - 77
Citations - 3605
Dimitrios A. Pappas is an academic researcher from Columbia University. The author has contributed to research in topics: Rheumatoid arthritis & Population. The author has an hindex of 17, co-authored 70 publications receiving 2851 citations. Previous affiliations of Dimitrios A. Pappas include Johns Hopkins University School of Medicine & Johns Hopkins University.
Papers
More filters
Journal ArticleDOI
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada,Yukinori Okada,Di Wu,Di Wu,Di Wu,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Shinji Yoshida,Robert R. Graham,A. Manoharan,Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler,Jeff Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye,Ding Feng Su,Jian Yang,Gang Xie,E.C. Keystone,Harm-Jan Westra,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andres Metspalu,Xuezhong Zhou,Namrata Gupta,Daniel B. Mirel,Eli A. Stahl,Dorothee Diogo,Dorothee Diogo,Jing Cui,Jing Cui,Katherine P. Liao,Katherine P. Liao,Michael H. Guo,Michael H. Guo,Keiko Myouzen,Takahisa Kawaguchi,Marieke J H Coenen,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,S. Louis Bridges,Alexandra Zhernakova,Alexandra Zhernakova,René E. M. Toes,Paul P. Tak,Paul P. Tak,Paul P. Tak,Corinne Miceli-Richard,So Young Bang,Hye Soon Lee,Javier Martin,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Solbritt Rantapää-Dahlqvist,Lisbeth Ärlestig,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Steve Eyre,Steve Eyre,John Bowes,John Bowes,Anne Barton,Niek de Vries,Larry W. Moreland,Lindsey A. Criswell,Elizabeth W. Karlson,Atsuo Taniguchi,Ryo Yamada,Michiaki Kubo,Jun Liu,Sang Cheol Bae,Jane Worthington,Jane Worthington,Leonid Padyukov,Lars Klareskog,Peter K. Gregersen,Soumya Raychaudhuri,Soumya Raychaudhuri,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Lude Franke,Peter M. Visscher,Matthew A. Brown,Hisashi Yamanaka,Tsuneyo Mimori,Atsushi Takahashi,Huji Xu,Timothy W. Behrens,Katherine A. Siminovitch,Shigeki Momohara,Fumihiko Matsuda,Kazuhiko Yamamoto,Robert M. Plenge,Robert M. Plenge +115 more
TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.
Journal ArticleDOI
Which spinal lesions are associated with new bone formation in patients with ankylosing spondylitis treated with anti-TNF agents? A long-term observational study using MRI and conventional radiography
Xenofon Baraliakos,Frank Heldmann,Johanna Callhoff,Joachim Listing,Thierry Appelboom,J Brandt,F. Van den Bosch,Maxime Breban,G.-R. Burmester,Maxime Dougados,P. Emery,Hill Gaston,Mathias Grunke,I E van der Horst-Bruinsma,R Landewe,Marjatta Leirisalo-Repo,Joachim Sieper,K. de Vlam,Dimitrios A. Pappas,Uta Kiltz,D. van der Heijde,Jürgen Braun +21 more
TL;DR: Parallel occurrence of inflammation and FD at baseline and development of FD without prior inflammation after 2’years were significantly associated with syndesmophyte formation after 5 years of anti-tumour necrosis factor (TNF) therapy, an argument against the TNF-brake hypothesis.
Journal ArticleDOI
Integration of sequence data from a consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene
Yukinori Okada,Dorothee Diogo,Dorothee Diogo,Jeff Greenberg,Faten Mouassess,Walid A L Achkar,Robert S. Fulton,Joshua C. Denny,Namrata Gupta,Daniel B. Mirel,S. Gabriel,Gang Li,Joel M. Kremer,Dimitrios A. Pappas,Robert J. Carroll,Anne E. Eyler,Gosia Trynka,Gosia Trynka,Eli A. Stahl,Jing Cui,Richa Saxena,Marieke J H Coenen,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,Anne Barton,Helena Canhão,João Eurico Fonseca,Niek de Vries,Paul P. Tak,Larry W. Moreland,S. Louis Bridges,Corinne Miceli-Richard,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Towfique Raj,Towfique Raj,Philip L. De Jager,Philip L. De Jager,Soumya Raychaudhuri,Jane Worthington,Leonid Padyukov,Lars Klareskog,Katherine A. Siminovitch,Peter K. Gregersen,Elaine R. Mardis,Thurayya Arayssi,L. Kazkaz,Robert M. Plenge,Robert M. Plenge +53 more
TL;DR: It is demonstrated that rare, low-frequency and common alleles at one gene locus, phospholipase B1 (PLB1), might contribute to risk of RA in a 4-generation consanguineous pedigree and also in unrelated individuals from the general population (European ancestry).
Journal ArticleDOI
Association of fine specificity and repertoire expansion of anticitrullinated peptide antibodies with rheumatoid arthritis associated interstitial lung disease
Jon T. Giles,Sonye K. Danoff,Jeremy Sokolove,Catriona A Wagner,Robert Winchester,Dimitrios A. Pappas,Stanley S. Siegelman,Geoff Connors,William H. Robinson,Joan M. Bathon +9 more
TL;DR: The findings of a broader ACPA repertoire in RA ILD suggest a possible role for ACPA in the pathogenesis of ILD.
Journal ArticleDOI
TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits
Dorothée Diogo,Lisa Bastarache,Katherine P. Liao,Robert R. Graham,Robert S. Fulton,Jeff Greenberg,Stephen Eyre,John Bowes,Jing Cui,Annette Lee,Dimitrios A. Pappas,Joel M. Kremer,Anne Barton,Marieke J H Coenen,Barbara Franke,Lambertus A. Kiemeney,Xavier Mariette,Corrine Richard-Miceli,Helena Canhão,João Eurico Fonseca,Niek de Vries,Paul P. Tak,J. Bart A. Crusius,Michael T. Nurmohamed,Fina A S Kurreeman,Ted R. Mikuls,Yukinori Okada,Yukinori Okada,Yukinori Okada,Eli A. Stahl,Eli A. Stahl,Eli A. Stahl,David E. Larson,Tracie L. Deluca,Michelle O'Laughlin,Catrina Fronick,Lucinda Fulton,Roman Kosoy,Michael Ransom,Tushar Bhangale,Ward Ortmann,Andrew Cagan,Vivian S. Gainer,Elizabeth W. Karlson,Isaac S. Kohane,Shawn N. Murphy,Javier Martín,Alexandra Zhernakova,Lars Klareskog,Leonid Padyukov,Jane Worthington,Elaine R. Mardis,Michael F. Seldin,Peter K. Gregersen,Timothy W. Behrens,Soumya Raychaudhuri,Joshua C. Denny,Robert M. Plenge,Robert M. Plenge,Robert M. Plenge +59 more
TL;DR: The role of TYK2 in the pathogenesis of RA, SLE and IBD is demonstrated, and supporting evidence forTYK2 as a promising drug target for the treatment of autoimmune diseases is provided.