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Dimitrius Leonardo Pitol
Researcher at University of São Paulo
Publications - 61
Citations - 885
Dimitrius Leonardo Pitol is an academic researcher from University of São Paulo. The author has contributed to research in topics: Ovariectomized rat & Medicine. The author has an hindex of 14, co-authored 54 publications receiving 744 citations. Previous affiliations of Dimitrius Leonardo Pitol include Sao Paulo State University.
Papers
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Journal ArticleDOI
Quercetin in w/o microemulsion: in vitro and in vivo skin penetration and efficacy against UVB-induced skin damages evaluated in vivo.
Fabiana T. M. C. Vicentini,Thais R. M. Simi,José Orestes Del Ciampo,Nilce de Oliveira Wolga,Dimitrius Leonardo Pitol,Mamie Mizusaki Iyomasa,M. Vitória L.B. Bentley,Maria José Vieira Fonseca +7 more
TL;DR: It is demonstrated that the daily application of the w/o microemulsion for up to 2 days did not cause skin irritation and significantly prevented the UVB irradiation-induced GSH depletion and secretion/activity of metalloproteinases.
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Metalloproteinase inhibition ameliorates hypertension and prevents vascular dysfunction and remodeling in renovascular hypertensive rats.
Michele M. Castro,Elen Rizzi,Lívia Figueiredo-Lopes,Karla Fernandes,Lusiane M. Bendhack,Dimitrius Leonardo Pitol,Raquel F. Gerlach,Jose E. Tanus-Santos +7 more
TL;DR: It is suggested that MMP-2 plays a role in 2K-1C hypertension and its structural and functional vascular changes, which were attenuated by doxycycline.
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The flavonoid quercetin inhibits titanium dioxide (TiO2)-induced chronic arthritis in mice.
Sergio M. Borghi,Sandra S. Mizokami,Felipe A. Pinho-Ribeiro,Victor Fattori,Jefferson Crespigio,Juliana Trindade Clemente-Napimoga,Marcelo Henrique Napimoga,Dimitrius Leonardo Pitol,João Paulo Mardegan Issa,Sandra Y. Fukada,Rubia Casagrande,Waldiceu A. Verri +11 more
TL;DR: The potential therapeutic applicability of the dietary flavonoid quercetin to reduce pain and inflammatory damages associated with prosthesis wear process-induced arthritis is demonstrated.
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Evaluation of protective effect of a water-in-oil microemulsion incorporating quercetin against UVB-induced damage in hairless mice skin.
Fabiana T. M. C. Vicentini,Yris Maria Fonseca,Dimitrius Leonardo Pitol,Mamie Mizusaki Iyomasa,M. Vitória L.B. Bentley,Maria José Vieira Fonseca +5 more
TL;DR: The results demonstrated that the w/o microemulsion containing quercetin reduced the incidence of histological skin alterations, mainly the connective-tissue damage, induced by exposure to UVB irradiation, which allows the suggestion that protective effects of this formulation against UV-induced responses are not secondary to the interference of UV transmission, as is usually done with UVB absorbers and sunscreens.
Journal ArticleDOI
Microwave-induced fast decalcification of rat bone for electron microscopic analysis: an ultrastructural and cytochemical study.
TL;DR: The results showed an increase in the decalcification rate in the specimens activated by microwaving and a reduction of total experiment time from 45 days in the conventional method to 48 hours in the microwave-aided method.