Dimphna H. Meijer

TL;DR: Tumour-derived microvesicles may provide diagnostic information and aid in therapeutic decisions for cancer patients through a blood test by incorporating an mRNA for a reporter protein into them, and it is demonstrated that messages delivered by microvesicle are translated by recipient cells.

TL;DR: More recent insights are summarized into the separate roles of these transcription factors in the postnatal brain during repair processes and in neurological disease states, including multiple sclerosis and malignant glioma.

TL;DR: It is shown that the proliferative function of Olig2 is controlled by developmentally regulated phosphorylation of a conserved triple serine motif within the amino-terminal domain, which maintains antineural (i.e., promitotic) functions that are reflected in human glioma cells and in a genetically defined murine model of primary gliomas.

TL;DR: A chimeric AAV capsid is obtained that transduces U87 cells at high efficiency (97% at a dose of 104 genome copies/cell), and at low doses it was 1.45–1.6-fold better than AAV2, which proved to be the most efficient parental capsid.

TL;DR: An accurate DIPG mouse model is described that can be of clinical relevance for testing experimental therapeutics in vivo and applied the bioluminescent Fluc signal to monitor tumor recurrence over time.