Diogo O. Souza

TL;DR: First direct in vivo evidence that caffeine and A(2A) receptor antagonists afford a protection against Abeta-induced amnesia, which prompts their interest for managing Alzheimer's disease is provided.

TL;DR: Results suggest that initial manic episodes are associated with both increased oxidative stress parameters and activated antioxidant defenses, which may be related to dysfunctions on energy metabolism and neuroplasticity pathways.

TL;DR: This review addresses the mechanisms of methylmercury (MeHg)-induced neurotoxicity by examining the role of oxidative stress in mediating neuronal damage and provides a mechanistic overview on oxidative stress induced by MeHg that is triggered by a series of molecular events such as activation of various kinases, stress proteins and other immediate early genes culminating in cell damage.

TL;DR: Investigating the effects of QA on the glutamatergic system from rat brain, it is demonstrated that QA (from 0.1 to 10mM) had no effect on synaptosomal L-[3H]glutamate uptake, and data provide additional evidence that neurotoxicity ofQA may be also related to disturbances on the glutamate transport system, which could result in the neurological manifestations observed when this organic acid accumulates in the brain.

TL;DR: First in vitro evidence to suggest that adenosine A2A receptors may be the molecular target responsible for the observed beneficial effects of caffeine consumption in the development of Alzheimer's disease is observed.