Author
Dipankar Basu
Bio: Dipankar Basu is an academic researcher. The author has contributed to research in topics: Goniothalamus. The author has an hindex of 1, co-authored 1 publications receiving 34 citations.
Topics: Goniothalamus
Papers
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TL;DR: Goniopedaline, a new phenanthrene lactam, aristololactam A-II and its N,O-diacetyl derivative, taliscanine (second natural occurrence), aurantiamide acetate and β-sitosterol and its β- d -glucoside have been isolated from the leaves and twigs of Goniothalamus sesquipedalis as discussed by the authors.
34 citations
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TL;DR: Aristolactams, having a phenanthrene chromophore are a small group of compounds mainly found in the Aristolochiaceae together with the aristolochic acids and 4,5-dioxoaporphines, which are reviewed and classified on the basis of their oxygenation pattern.
172 citations
TL;DR: The crude methanol extract of G. scortechinii showed a good and broad spectrum of antibacterial activity against both Gram-negative and Gram-positive bacteria and the growth inhibition of several nosocomial bacteria by Goniothalamus.
Abstract: Irrespective of the presence of cytotoxic acetogenins and styryl-lactones in the genus Goniothalamus, only 22 species in the genus Goniothalamus, out of 160 species (13.7%) have so far been investigated. In an effort to promote further research on the genus Goniothalamus which could represent a source of drugs for the treatment of cancers and bacterial infections, this work offers a broad analysis of current knowledge on Goniothalamus species. Therefore, it includes (i) taxonomy (ii) botanical description (iii) traditional medicinal uses and (iv) phytochemical and pharmacological studies. We discuss the molecular mechanisms of actions of acetogenins and styryl-lactones, with some emphasis on the possible involvement of protein kinase, Bax and TRAIL receptors in the cytotoxic effects of styryl-lactones. We also report (v) the growth inhibition of several nosocomial bacteria by Goniothalamus. scortechinii. The crude methanol extract of G. scortechinii showed a good and broad spectrum of antibacterial activity against both Gram-negative and Gram-positive bacteria.
109 citations
TL;DR: Twelve natural products, including two new compounds, were isolated from the bark of the Malaysian tree Goniothalamus borneensis and evaluated for their cytotoxic activity, including goniothalesdiol 1a and goniothalactam 2, which were elucidated by spectroscopy including 2D-NMR spectroscopic.
74 citations
TL;DR: The leishmanicidal, antimicrobial, antitumor, cytotoxic, and antimalarial activities observed for these alkaloids observed for species belonging to the Annonaceae family are highlighted.
Abstract: This chapter presents an overview of the chemistry and pharmacology of the alkaloids found in species of the Annonaceae family. The occurrence of alkaloids from Annonaceae species, as well as their chemical structures and pharmacological activities are summarized in informative and easy-to-understand tables. Within the Annonaceae family, the genera Annona, Duguetia, and Guatteria have led to many important publications. Valuable and comprehensive information about the structure of these alkaloids is provided. The alkaloids of the aporphine type represent the predominant group in this family. Many of the isolated alkaloids exhibit unique structures. In addition to the chemical structures, the pharmacological activities of some alkaloids are also presented in this chapter. Thus, the leishmanicidal, antimicrobial, antitumor, cytotoxic, and antimalarial activities observed for these alkaloids are highlighted. The chapter is presented as a contribution for the scientific community, mainly to enable the search for alkaloids in species belonging to the Annonaceae family.
58 citations
56 citations