Diren Beyoğlu

TL;DR: The findings of a plasma metabolomic investigation of HCC patients by ultraperformance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS), random forests machine learning algorithm, and multivariate data analysis found that HCC was associated with increased plasma levels of glycodeoxycholate, de oxygencholate 3-sulfate, and bilirubin.

TL;DR: The metabolomic window into hepatobiliary disease sheds new light on the systems pathology of the liver.

TL;DR: Tissue metabolomics yielded precise biochemical information regarding HCC tumor metabolic remodeling from mitochondrial oxidation to aerobic glycolysis and the impact of molecular subtypes on this process.

TL;DR: The Tg-2D6 mouse model may serve as a valuable in vivo tool to determine CYP2D 6-involved neurophysiological metabolism and function, and anxiety tests indicate T g- 2D6 mice have a higher capability to adapt to anxiety.

TL;DR: Although not yet established as a clinical trial patient prescreening procedure, metabolomics shows considerable promise in this regard and can be certain that metabolomics will join genomics and transcriptomics in lubricating the wheels of clinical drug development in the near future.