D
Dirk B. Mendel
Researcher at Utah State University
Publications - 20
Citations - 1248
Dirk B. Mendel is an academic researcher from Utah State University. The author has contributed to research in topics: Neuraminidase & Orthomyxoviridae. The author has an hindex of 13, co-authored 20 publications receiving 1211 citations.
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Journal ArticleDOI
Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection
Dirk B. Mendel,Chun Y. Tai,Paul A. Escarpe,Weixing Li,Robert W. Sidwell,John H. Huffman,Clive Sweet,Kenneth J. Jakeman,James R. Merson,Steven A. Lacy,Willard Lew,Matthew A. Williams,Lijun Zhang,Ming S. Chen,Norbert Bischofberger,Choung U. Kim +15 more
TL;DR: The results indicate that GS 4104 is a novel, orally active antiviral agent with the potential to be used for the prophylaxis and treatment of influenza A and B virus infections.
Journal ArticleDOI
Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071
Weixing Li,Paul A. Escarpe,Eugene J. Eisenberg,Kenneth C. Cundy,Clive Sweet,Kenneth J. Jakeman,James R. Merson,Willard Lew,Matthew A. Williams,Lijun Zhang,Choung U. Kim,Norbert Bischofberger,Ming S. Chen,Dirk B. Mendel +13 more
TL;DR: Results demonstrate that GS 4104 is an orally bioavailable prodrug of GS 4071 in animals and that it has the potential to be an oral agent for the prevention and treatment of influenza A and B virus infections in humans.
Journal ArticleDOI
Mechanism by Which Mutations at His274 Alter Sensitivity of Influenza A Virus N1 Neuraminidase to Oseltamivir Carboxylate and Zanamivir
TL;DR: The conclusion that the conformational change of Glu276 is restricted in the His274Tyr and His274Phe mutant NA upon oseltamivir carboxylate binding is supported, which indicates that the volume occupied by the amino acid side chain at position 274 can influence the sensitivities of influenza N1 NA but not of N2 NA to both oselTamIVir car boxylate and zanamivirs.
Journal ArticleDOI
Characterization of Human Influenza Virus Variants Selected In Vitro in the Presence of the Neuraminidase Inhibitor GS 4071
Chun Y. Tai,Paul A. Escarpe,Robert W. Sidwell,Matthew A. Williams,Willard Lew,Huiwei Wu,Choung U. Kim,Dirk B. Mendel +7 more
TL;DR: Results suggest that although the R292K neuraminidase mutation confers high-level resistance to GS 4071 in vitro, its effect on viral virulence is likely to render this mutation of limited clinical significance.
Journal ArticleDOI
1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo.
N Bischofberger,Michael J. M. Hitchcock,M S Chen,D.B. Barkhimer,K C Cundy,K M Kent,S A Lacy,William A. Lee,Z H Li,Dirk B. Mendel +9 more
TL;DR: Evaluated as a novel antiviral agent, cHPMPC was found to be stable on incubation in human plasma and human liver homogenates and Nephrotoxicity, which is the dose-limiting toxicity of HPMPC, was assessed in a 14-day repeated-dose toxicity study in rats.