D
Dirk Roos
Researcher at University of Amsterdam
Publications - 402
Citations - 28176
Dirk Roos is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Chronic granulomatous disease & NADPH oxidase. The author has an hindex of 92, co-authored 400 publications receiving 26627 citations. Previous affiliations of Dirk Roos include Netherlands Cancer Institute & Radboud University Nijmegen.
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FcγRIIIa-158V/F Polymorphism Influences the Binding of IgG by Natural Killer Cell FcγRIIIa, Independently of the FcγRIIIa-48L/R/H Phenotype
TL;DR: Differences in IgG binding among the three Fc gammaRIIIa-48L/R/H isoforms are a consequence of the linked, biallelic Fc Gamma receptor IIIa-158V/F polymorphism at amino-acid position 158.
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Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.
TL;DR: Since enhanced O-2 production was stimulated by immune reactants in the absence of phagocytosis, the O-.2 generating system is very likely associated with the external plasma membrane of the polymorphonuclear leukocyte.
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Chronic Granulomatous Disease: The European Experience
J. Merlijn van den Berg,Elsbeth van Koppen,Anders Åhlin,Bernd H. Belohradsky,Ewa Bernatowska,Lucien Corbeel,Teresa Espanol,Alain Fischer,Magdalena Kurenko-Deptuch,Richard Mouy,Theoni Petropoulou,Joachim Roesler,Reinhard Seger,Marie José Stasia,Niels Henrik Valerius,Ron S. Weening,Baruch Wolach,Dirk Roos,Taco W. Kuijpers +18 more
TL;DR: Detailed clinical data from 429 European patients with CGD are collected and analyzed to provide further insight in the clinical course of CGD in Europe and hopefully can help to increase awareness and optimize the treatment of these patients.
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Neutrophils: Between host defence, immune modulation, and tissue injury
Philipp Kruger,Mona Saffarzadeh,Alexander N.R. Weber,Nikolaus Rieber,Markus P. Radsak,Horst von Bernuth,Charaf Benarafa,Dirk Roos,Julia Skokowa,Dominik Hartl +9 more
TL;DR: Current understanding of neutrophils in host-pathogen interactions and disease involvement is summarized, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.
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Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro
Christa H. E. Homburg,M. de Haas,A. E. G. K. Von Dem Borne,Arthur J. Verhoeven,Chris P. M. Reutelingsperger,Dirk Roos +5 more
TL;DR: The results indicate that soluble Fc gamma RIII in body fluids might be derived for a large part from neutrophils undergoing apoptosis in the tissues.