Dirk Wenzel

TL;DR: It is found that cargo is segregated into distinct subdomains on the endosomal membrane and that the transfer of exosome-associated domains into the lumen of theendosome did not depend on the function of the ESCRT (endosomal sorting complex required for transport) machinery, but required the sphingolipid ceramide.

TL;DR: In the plasmalemma, syntaxins are concentrated in 200 nm large, cholesterol‐dependent clusters at which secretory vesicles preferentially dock and fuse, which suggests that high local concentrations of SNAREs are required for efficient fusion.

TL;DR: Older Pink1−/− mice show increasing mitochondrial dysfunction resulting in impaired neural activity similar to PD, in absence of overt neuronal death.

TL;DR: N nanoscale resolution in far-field fluorescence microscopy is demonstrated using reversible photoswitching and localization of individual fluorophores at comparatively fast recording speeds and from the interior of intact cells by asynchronously recording the photon bursts of individual molecular switching cycles.

TL;DR: It is shown that lymphoma exosomes shield target cells from antibody attack and that exosome biogenesis is modulated by the lysosome-related organelle-associated ATP-binding cassette (ABC) transporter A3 (ABCA3), and mechanisms of cancer cell resistance to drugs and antibodies are linked in an ABCA3-dependent pathway of exosomal secretion.