Ditsa Levanon

TL;DR: The data indicate that cytokine gene expression in TH1 cells may be controlled by a feed-forward regulatory circuit in which T-bet induces Runx3 and then 'partners' with Runx 3 to direct lineage-specific gene activation and silencing.

TL;DR: It is shown that AML1 and LEF-1 can act, through recruitment of the corepressor TLE1, as transcriptional repressors in TCR regulation and Wnt/Wg signaling.

TL;DR: It is shown that effector CTL differentiation occurs in two sequential phases in vitro, characterized by early induction of T-bet and late induction of Eomesodermin (Eomes), T-box transcription factors that regulate the early and late phases of interferon γ expression, respectively.

TL;DR: It is shown that Runx3‐deficient mice develop severe limb ataxia due to disruption of monosynaptic connectivity between intra spinal afferents and motoneurons, and the underlying cause is a loss of DRG proprioceptive neurons.

TL;DR: Analysis of AML1 and AML2 expression in hematopoietic cell lines revealed a distinct pattern of expression, and their C-terminal halves were particularly rich in proline and serine residues.