D
Divya Ramamoorthy
Researcher at Massachusetts Institute of Technology
Publications - 12
Citations - 513
Divya Ramamoorthy is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Medicine & Proteome. The author has an hindex of 4, co-authored 7 publications receiving 328 citations. Previous affiliations of Divya Ramamoorthy include University of Texas at Austin.
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Journal ArticleDOI
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
Alexandra B Keenan,Sherry L. Jenkins,Kathleen M. Jagodnik,Simon Koplev,Edward He,Denis Torre,Zichen Wang,Anders B. Dohlman,Moshe C. Silverstein,Alexander Lachmann,Maxim V. Kuleshov,Avi Ma'ayan,Vasileios Stathias,Raymond Terryn,Daniel J. Cooper,Michele Forlin,Amar Koleti,Dusica Vidovic,Caty Chung,Stephan C. Schürer,Jouzas Vasiliauskas,Marcin Pilarczyk,Behrouz Shamsaei,Mehdi Fazel,Yan Ren,Wen Niu,Nicholas A. Clark,Shana White,Naim Al Mahi,Lixia Zhang,Michal Kouril,John F. Reichard,Siva Sivaganesan,Mario Medvedovic,Jaroslaw Meller,Rick J. Koch,Marc R. Birtwistle,Ravi Iyengar,Eric A. Sobie,Evren U. Azeloglu,Julia A. Kaye,Jeannette Osterloh,Kelly Haston,Jaslin Kalra,Steve Finkbiener,Jonathan Z. Li,Pamela Milani,Miriam Adam,Renan Escalante-Chong,Karen Sachs,Alexander LeNail,Divya Ramamoorthy,Ernest Fraenkel,Gavin Daigle,Uzma Hussain,Alyssa Coye,Jeffrey D. Rothstein,Dhruv Sareen,Loren Ornelas,Maria G. Banuelos,Berhan Mandefro,Ritchie Ho,Clive N. Svendsen,Ryan G. Lim,Jennifer Stocksdale,Malcolm Casale,Terri G. Thompson,Jie Wu,Leslie M. Thompson,Victoria Dardov,Vidya Venkatraman,Andrea Matlock,Jennifer E. Van Eyk,Jacob D. Jaffe,Malvina Papanastasiou,Aravind Subramanian,Todd R. Golub,Sean D. Erickson,Mohammad Fallahi-Sichani,Marc Hafner,Nathanael S. Gray,Jia-Ren Lin,Caitlin E. Mills,Jeremy L. Muhlich,Mario Niepel,Caroline E. Shamu,Elizabeth H. Williams,David Wrobel,Peter K. Sorger,Laura M. Heiser,Joe W. Gray,James E. Korkola,Gordon B. Mills,Mark A. LaBarge,Mark A. LaBarge,Heidi S. Feiler,Mark A. Dane,Elmar Bucher,Michel Nederlof,Damir Sudar,Sean M. Gross,David Kilburn,Rebecca Smith,Kaylyn Devlin,Ron Margolis,Leslie Derr,Albert Lee,Ajay Pillai +107 more
TL;DR: The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders.
Journal ArticleDOI
Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups
Tenley C. Archer,Tobias Ehrenberger,Filip Mundt,Filip Mundt,Maxwell P. Gold,Karsten Krug,Clarence K. Mah,Elizabeth L. Mahoney,Elizabeth L. Mahoney,Colin J. Daniel,Alexander LeNail,Divya Ramamoorthy,Philipp Mertins,D. R. Mani,Hailei Zhang,Michael A. Gillette,Michael A. Gillette,Karl R. Clauser,Michael S. Noble,Lauren C. Tang,Jessica Pierre-Francois,Jessica Pierre-Francois,Jacob Silterra,James Jensen,Pablo Tamayo,Andrey Korshunov,Andrey Korshunov,Stefan M. Pfister,Stefan M. Pfister,Marcel Kool,Paul A. Northcott,Paul A. Northcott,Rosalie C. Sears,Jonathan O. Lipton,Jonathan O. Lipton,Steven A. Carr,Jill P. Mesirov,Scott L. Pomeroy,Scott L. Pomeroy,Scott L. Pomeroy,Ernest Fraenkel,Ernest Fraenkel +41 more
TL;DR: This study quantitatively profiled global proteomes and phospho-proteomes of 45 medulloblastoma samples and found kinases associated with subtypes and showed that inhibiting PRKDC sensitizes MYC-driven cells to radiation.
Posted ContentDOI
Answer ALS: A Large-Scale Resource for Sporadic and Familial ALS Combining Clinical Data with Multi-Omics Data from Induced Pluripotent Cell Lines
Jeffrey D. Rothstein,James D. Berry,Clive N. Svendsen,Leslie M. Thompson,Steven Finkbeiner,Jennifer E. Van Eyk,Ernest Fraenkel,Merit Cudkowicz,Nicholas J. Maragakis,Dhruv Sareen,Raquel Norel,Victoria Dardov,Alyssa N. Coyne,Aaron T. Frank,Andrea Matlock,Rakhi Pandey,Vineet Vibhav,Leandro Lima,Jie Wu,Divya Ramamoorthy,Ryan Lim,Julia A. Kaye,Jonathan Z. Li,Terri G. Thompson,Emily G. Baxi,Answer Als +25 more
TL;DR: This community based clinical and science program provides for the identification of distinct reliably identifiable subgroups among the sporadic and familial patients and the great utility in iPS based approaches to disease pathophysiology and therapy discovery.
Journal ArticleDOI
Maintenance of HL-1 cardiomyocyte functional activity in PEGylated fibrin gels
TL;DR: Data is presented suggesting the potential use of PEGylated fibrin gel layers to prepare a sheet‐like construct for myocardial regeneration, and optimizing the mechanical properties of the hydrogel would enhance contractility.
Journal ArticleDOI
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients.
Jonathan Z. Li,Ryan G. Lim,Julia A. Kaye,Victoria Dardov,Alyssa N. Coyne,Jie Wu,Pamela Milani,Andrew Cheng,Terri G. Thompson,Loren Ornelas,Aaron P. Frank,Miriam Adam,Maria G. Banuelos,Malcolm Casale,Veerle Cox,Renan Escalante-Chong,J. Gavin Daigle,Emilda Gomez,Lindsey R. Hayes,Ronald Holewenski,Susan Lei,Alexander LeNail,Leandro Lima,Berhan Mandefro,Andrea Matlock,Lindsay Panther,Natasha L. Patel-Murray,Jacqueline T. Pham,Divya Ramamoorthy,Karen Sachs,Brandon Shelley,Jennifer Stocksdale,Hannah Trost,Mark Wilhelm,Vidya Venkatraman,Brook T. Wassie,Stacia Wyman,Stephanie Y. Yang,Jennifer E. Van Eyk,Thomas E. Lloyd,Steven Finkbeiner,Ernest Fraenkel,Jeffrey D. Rothstein,Dhruv Sareen,Clive N. Svendsen,Leslie M. Thompson +45 more
TL;DR: In this article, the authors investigated DNA, RNA, epigenetics, and proteins in iPSC-derived motor neurons from patients with ALS carrying hexanucleotide expansions in C9ORF72.