D
Dmitry I. Gabrilovich
Researcher at AstraZeneca
Publications - 297
Citations - 62935
Dmitry I. Gabrilovich is an academic researcher from AstraZeneca. The author has contributed to research in topics: Immune system & Myeloid-derived Suppressor Cell. The author has an hindex of 95, co-authored 280 publications receiving 52009 citations. Previous affiliations of Dmitry I. Gabrilovich include Wistar Institute & University of Pennsylvania.
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Journal ArticleDOI
Myeloid-derived suppressor cells as regulators of the immune system.
TL;DR: The origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit are discussed.
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Coordinated regulation of myeloid cells by tumours
TL;DR: This work considers myeloid cells as an intricately connected, complex, single system and focuses on how tumours manipulate the myeloids system to evade the host immune response.
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Understanding the tumor immune microenvironment (TIME) for effective therapy.
Mikhail Binnewies,Edward W. Roberts,Kelly Kersten,Vincent Chan,Douglas F. Fearon,Miriam Merad,Lisa M. Coussens,Dmitry I. Gabrilovich,Suzanne Ostrand-Rosenberg,Suzanne Ostrand-Rosenberg,Catherine C. Hedrick,Robert H. Vonderheide,Mikael J. Pittet,Rakesh K. Jain,Weiping Zou,T. Kevin Howcroft,Elisa C. Woodhouse,Robert A. Weinberg,Matthew F. Krummel +18 more
TL;DR: By parsing the unique classes and subclasses of tumor immune microenvironment (TIME) that exist within a patient’s tumor, the ability to predict and guide immunotherapeutic responsiveness will improve, and new therapeutic targets will be revealed.
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Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
Vincenzo Bronte,Sven Brandau,Shu Hsia Chen,Mario P. Colombo,Alan B. Frey,Tim F. Greten,Susanna Mandruzzato,Peter J. Murray,Augusto C. Ochoa,Suzanne Ostrand-Rosenberg,Paulo C. Rodriguez,Antonio Sica,Viktor Umansky,Viktor Umansky,Robert H. Vonderheide,Dmitry I. Gabrilovich +15 more
TL;DR: The authors identify the challenges and proposed set of minimal reporting guidelines for mouse and human MDSC are a heterogeneous population expanded in cancer and other chronic inflammatory conditions.
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Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells.
Dmitry I. Gabrilovich,Dmitry I. Gabrilovich,Hailei L. Chen,Khaled R. Girgis,H. Thomas Cunningham,Geralyn M. Meny,Sorena Nadaf,Sorena Nadaf,Denise Kavanaugh,David P. Carbone,David P. Carbone +10 more
TL;DR: It is shown that human cancer cell lines release a soluble factor or factors that dramatically affect DC maturation from precursors without affecting the function of relatively mature DCs, and one factor responsible for these effects was identified as vascular endothelial growth factor (VEGF).